ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2018
Intra-operative characterisation of subthalamic oscillations in Parkinson's disease.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- Mechanism and progress of deep brain stimulation in the treatment of neurological and psychiatric disorders.MedScience · 2026Review
- N2GNet tracks gait performance from subthalamic neural signals in Parkinson's disease.NPJ digital medicine · 2025Article
- N2GNet tracks gait performance from subthalamic neural signals in Parkinson's disease.Research square · 2024Article
- Spectral Topography of the Subthalamic Nucleus to Inform Next-Generation Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Early decreases in cortical mid-gamma peaks coincide with the onset of motor deficits and precede exaggerated beta build-up in rat models for Parkinson's disease.Neurobiology of disease · 2021Article
- Directional Local Field Potentials in the Subthalamic Nucleus During Deep Brain Implantation of Parkinson's Disease Patients.Frontiers in human neuroscience · 2020Article
- Subthalamic Nucleus and Sensorimotor Cortex Activity During Speech Production.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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7 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveThis study aims to use the activities recorded directly from the deep brain stimulation (DBS) electrode to address the focality and distinct nature of the local field potential (LFP) activities of different frequency.
methodsPre-operative and intra-operative magnetic resonance imaging (MRI) were acquired from patients with Parkinson's disease (PD) who underwent DBS in the subthalamic nucleus and intra-operative LFP recording at rest and during cued movements. Images were reconstructed and 3-D visualized using Lead-DBS® toolbox to determine the coordinates of contact. The resting spectral power and movement-related power modulation of LFP oscillations were estimated.
resultsBoth subthalamic LFP activity recorded at rest and its modulation by movement had focal maxima in the alpha, beta and gamma bands. The spatial distribution of alpha band activity and its modulation was significantly different to that in the beta band. Moreover, there were significant differences in the scale and timing of movement related modulation across the frequency bands.
conclusionSubthalamic LFP activities within specific frequency bands can be distinguished by spatial topography and pattern of movement related modulation. SIGNIFICANCE: Assessment of the frequency, focality and pattern of movement related modulation of subthalamic LFPs reveals a heterogeneity of neural population activity in this region. This could potentially be leveraged to finesse intra-operative targeting and post-operative contact selection.
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