ReviewFree radical biology & medicine2018
Ascorbic acid metabolism and functions: A comparison of plants and mammals.
Review in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
260 citing papers in PubMed, 619 citations in OpenAlex.
- Ascorbic and salicylic acid regulate antioxidant defense and drought stress responses in maize.Plant signaling & behavior · 2026Article
- L-Threonic Acid Inhibits Pathological Retinal Neovascularization by Modulation of CCL3-CCR5 Signaling Pathway.Investigative ophthalmology & visual science · 2026Article
- Self-Feeding Living Materials Enabled by Cell Responsive Glycogen Nanoparticles as Metabolic Batteries.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Crystal structure of rice L-galactose dehydrogenase.Acta crystallographica. Section F, Structural biology communications · 2026Article
- Bacillus amyloliquefaciens-induced resistance against the olive knot disease: An integrated transcriptomic and metabolomic analysis.Pest management science · 2026Article
- Antioxidant Compounds in Microalgae and Cyanobacteria: A Sustainable Source of Bioactive Molecules.Marine drugs · 2026Review
- Multi-Level Physiological and Metabolomic Responses ofPlants (Basel, Switzerland) · 2026Article
- Natural and CRISPR/Cas9 Editing Variations of Dual-uORFs Synergistically Increase the Nutritional Value of Silage Maize Feed.Plant biotechnology journal · 2026Article
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- The transcription factor AebHLH89 activatesHorticulture research · 2026Article
- Clarifying the molecular mechanisms underlying the lethal in vitro cellular effects and mild organismal phenotype of SOD1 loss.Scientific reports · 2026Article
- Targeting oxidative stress pathways in epilepsy: mechanistic insights into the role of ascorbic acid.Molecular biology reports · 2026Review
- Gold Nanoparticle Complexes with PAMAM Dendrimers for In Vitro Cancer Cytotoxicity Assessment: Synthesis via Ascorbic Acid Reduction.Molecules (Basel, Switzerland) · 2026Article
- A copper-dependent redox-based hydrogen peroxide perception in plants.Nature communications · 2026Article
- Effects of Melatonin and Calcium Chloride Treatment on the Quality of Chinese Kale Sprouts.Foods (Basel, Switzerland) · 2026Article
- Integrated transcriptomic and metabolomic analysis reveals the salt tolerance mechanisms in Lagerstroemia indica.BMC plant biology · 2026Article
- LED Light Intensity Regulates Nitrogen Assimilation Enzyme Activity and Metabolic Responses in Iceberg and Leaf Lettuce (Plants (Basel, Switzerland) · 2026Article
- Enhanced physiological performance and induced genetic variation in radish (Raphanus sativus L.) under gamma irradiation via silver chromate/aluminum-organic framework application.BMC plant biology · 2026Article
200 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Ascorbic acid is synthesised by eukaryotes, the known exceptions being primates and some other animal groups which have lost functional gulonolactone oxidase. Prokaryotes do not synthesise ascorbate and do not need an ascorbate supply, so the functions that are essential for mammals and plants are not required or are substituted by other compounds. The ability of ascorbate to donate electrons enables it to act as a free radical scavenger and to reduce higher oxidation states of iron to Fe
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.