Evidence map›Paper›PMID 29567389›Full record

ReviewBiomaterials2018

Polyphenol uses in biomaterials engineering.

Amin Shavandi, Alaa El-Din Ahmed Bekhit, Pouya Saeedi, Zohreh Izadifar, Adnan A Bekhit, Ali Khademhosseini

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 217 citations in OpenAlex.

  1. Review
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  16. Hyaluronic Acid/Ellagic Acid as Materials for Potential Medical Application.International journal of molecular sciences · 2024
    Article
  17. Article
  18. Article
  19. Role of Polyphenols, Their Nano-formulations, and Biomaterials in Diabetic Wound Healing.Endocrine, metabolic & immune disorders drug targets · 2024
    Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 5 countries.

Amin ShavandiDepartment of Food Science, University of Otago, Dunedin, New Zealand. Electronic address: amin.shavandi@otago.ac.nz.
Alaa El-Din Ahmed BekhitDepartment of Food Science, University of Otago, Dunedin, New Zealand.
Pouya SaeediDepartment of Human Nutrition, University of Otago, Dunedin, New Zealand.
Zohreh IzadifarThe Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Canada.
Adnan A BekhitDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt; Pharmacy Program, Allied Health Department, College of Health Sciences, University of Bahrain, P.O. Box 32038, Kingdom of Bahrain.
Ali KhademhosseiniDepartment of Bioengineering, Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, USA; Department of Radiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA; Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, USA; California NanoSystems Institute (CNSI), University of California-Los Angeles, Los Angeles, CA, USA. Electronic address: khademh@ucla.edu.
University of Otago · NZSamueli Institute · USUniversity of Toronto · CA

Funding

Hemorrhage control in the irreversible anticoagulated patientR01HL137193 · NHLBI · MAYO CLINIC ARIZONA · PI OKLU, RAHMI · 2017 to 2021
$3.0M
Whitlockite nanoparticles for inducing bone regenerationR21AR070647 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2016 to 2017
$423k
NHLBI NIH HHS R01 HL137193NIAMS NIH HHS R21 AR070647
6 · The paper itself

Abstract

Polyphenols are micronutrients obtained from diet that have been suggested to play an important role in health. The health benefits of polyphenols and their protective effects in food systems as antioxidant compounds are well known and have been extensively investigated. However, their functional roles as a "processing cofactor" in tissue engineering applications are less widely known. This review focuses on the functionality of polyphenols and their application in biomaterials. Polyphenols have been used to stabilize collagen and to improve its resistance to degradation in biological systems. Therefore, they have been proposed to improve the performance of biomedical devices used in cardiovascular systems by improving the mechanical properties of grafted heart valves, enhancing microcirculation through the relaxation of the arterial walls and improving the capillary blood flow and pressure resistance. Polyphenols have been found to stimulate bone formation, mineralization, as well as the proliferation, differentiation, and the survival of osteoblasts. These effects are brought about by the stimulatory effect of polyphenols on osteoblast cells and their protective effect against oxidative stress and inflammatory cytokines. In addition, polyphenols inhibit the differentiation of the osteoclast cells. Collectively, these actions lead to promote bone formation and to reduce bone resorption, respectively. Moreover, polyphenols can increase the cross-linking of dentine and hence its mechanical stability. Overall, polyphenols provide interesting properties that will stimulate further research in the bioengineering field.

Indexed as

AnimalsAntioxidantsBiocompatible MaterialsBioengineeringCollagenCross-Linking ReagentsHumansOrgan PreservationPolyphenolsProtease InhibitorsTissue EngineeringAntioxidantsBiocompatible MaterialsCollagenCross-Linking ReagentsPolyphenolsProtease InhibitorsCollagen cross-linkerGrafted heart valvesPolyphenolsProteolytic enzyme inhibitor

Identifiers

PMID29567389
PMCPMC5973878
OpenAlexW2791032058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.