ArticleJournal of food and drug analysis2018
HPTLC-FLD-SERS as a facile and reliable screening tool: Exemplarily shown with tyramine in cheese.
Article in Journal of food and drug analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 19 citations in OpenAlex.
- HPTLC + SRES screening of pesticide for point-of-care application as shown with thiram in juice.Food chemistry: X · 2023Article
- Tectomer-Mediated Optical Nanosensors for Tyramine Determination.Sensors (Basel, Switzerland) · 2023Article
- HPTLC screening of saccharin in beverages by densitometry quantification and SERS confirmation.RSC advances · 2022Article
- Optical sensors for determination of biogenic amines in food.Analytical and bioanalytical chemistry · 2020Review
- rGO-NS SERS-based coupled chemometric prediction of acetamiprid residue in green tea.Journal of food and drug analysis · 2019Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serious cytotoxicity of tyramine attracted marked attention as it induced necrosis of human intestinal cells. This paper presented a novel and facile high performance thin-layer chromatography (HPTLC) method tailored for screening tyramine in cheese. Separation was performed on glass backed silica gel plates, using methanol/ethyl acetate/ammonia (6/4/1 v/v/v) as the mobile phase. Special efforts were focused on optimizing conditions (substrate preparation, laser wavelength, salt types and concentrations) of surface enhanced Raman spectroscopy (SERS) measurements directly on plates after derivatization, which enabled molecule-specific identification of targeted bands. In parallel, fluorescent densitometry (FLD) scanning at 380</400 nm offered satisfactory quantitative performances (LOD 9 ng/zone, LOQ 17 ng/zone, linearity 0.9996 and %RSD 6.7). Including a quick extraction/cleanup step, the established method was successfully validated with different cheese samples, both qualitatively (straightforward confirmation) and quantitatively (recovery rates from 83.7 to 108.5%). Beyond this application, HPTLC-FLD-SERS provided a new horizon in fast and reliable screening of sophisticated samples like food and herb drugs, striking an excellent balance between specificity, sensitivity and simplicity.
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