Tauomics and Kinetics in Human Neurons and Biological Fluids.

Henrik Zetterberg

Abstract readComment

In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

N-terminal and mid-region tau fragments as fluid biomarkers in neurological diseases.Brain : a journal of neurology · 2022
Article
Mass spectrometry analysis of tau and amyloid-beta in iPSC-derived models of Alzheimer's disease and dementia.Journal of neurochemistry · 2021
Review
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease.Journal of internal medicine · 2021
Review
Circulating Brain Injury Exosomal Proteins following Moderate-To-Severe Traumatic Brain Injury: Temporal Profile, Outcome Prediction and Therapy Implications.Cells · 2020
Article
Sex Differences in Circulating T-Tau Trajectories After Sports-Concussion and Correlation With Outcome.Frontiers in neurology · 2020
Article
Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2019
Article
Association of Cerebrospinal Fluid Neurofilament Light Protein With Risk of Mild Cognitive Impairment Among Individuals Without Cognitive Impairment.JAMA neurology · 2019
Article
Differential effects of neurodegeneration biomarkers on subclinical cognitive decline.Alzheimer's & dementia (New York, N. Y.) · 2019
Article

4 · The record

Corrections and comments

Comment on
Tau Kinetics in Neurons and the Human Central Nervous System.2018

5 · Who and what money

Authors and funding

1 author.

Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK; UK Dementia Research Institute at UCL, London, UK. Electronic address: henrik.zetterberg@clinchem.gu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Neuron, Sato et al. (2018) combine proteomics and a stable isotope labeling method to examine different forms of tau and their kinetics in human neurons, brain, and cerebrospinal fluid and how these properties relate to clinical state and pathology in Alzheimer's disease.

Indexed as

Alzheimer DiseaseBrainHumansKineticsNeuronstau Proteinstau Proteins

Identifiers

PMID29566788

DOI10.1016/j.neuron.2018.02.030

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.