ArticleBiomedical engineering online2018
A new CFD based non-invasive method for functional diagnosis of coronary stenosis.
Article in Biomedical engineering online, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- The Diagnostic and Prognostic Impact of Cardiovascular Magnetic Resonance in Ischemic Heart Disease: A Systematic Review.Journal of clinical medicine · 2026Review
- The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis.Open medicine (Warsaw, Poland) · 2025Article
- Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics.BMC cardiovascular disorders · 2023Article
- CFD Computation of Flow Fractional Reserve (FFR) in Coronary Artery Trees Using a Novel Physiologically Based Algorithm (PBA) Under 3D Steady and Pulsatile Flow Conditions.Bioengineering (Basel, Switzerland) · 2023Article
- New computational fluid dynamics-based method for morphological and functional assessment in cardiovascular skill training.Journal of vascular surgery cases and innovative techniques · 2022Article
- Effect of guidewire insertion in fractional flow reserve procedure for real geometry using computational fluid dynamics.Biomedical engineering online · 2021Article
- Application of physics-based flow models in cardiovascular medicine: Current practices and challenges.Biophysics reviews · 2021Review
- Pressure-flow curve derived from coronary CT angiography for detection of significant hemodynamic stenosis.European radiology · 2020Article
- Validation and Diagnostic Performance of a CFD-Based Non-invasive Method for the Diagnosis of Aortic Coarctation.Frontiers in neuroinformatics · 2020Article
- A review on low-dimensional physics-based models of systemic arteries: application to estimation of central aortic pressure.Biomedical engineering online · 2019Review
- Hemodynamic performance within crossed stent grafts: computational and experimental study on the effect of cross position and angle.Biomedical engineering online · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAccurate functional diagnosis of coronary stenosis is vital for decision making in coronary revascularization. With recent advances in computational fluid dynamics (CFD), fractional flow reserve (FFR) can be derived non-invasively from coronary computed tomography angiography images (FFR
methodsInstead of modeling maximal hyperemia condition, a series of boundary conditions are specified and those simulated results are combined to provide a pressure-flow curve for a stenosis. Then, functional diagnosis of stenosis is assessed based on parameters derived from the obtained pressure-flow curve.
resultsThe proposed method is applied to both idealized and patient-specific models, and validated with invasive FFR in six patients. Results show that additional hemodynamic information about the flow resistances of a stenosis is provided, which cannot be directly obtained from anatomy information. Parameters derived from the simulated pressure-flow curve show a linear and significant correlations with invasive FFR (r > 0.95, P < 0.05).
conclusionThe proposed method can assess flow resistances by the pressure-flow curve derived parameters without modeling of maximal hyperemia condition, which is a new promising approach for non-invasive functional assessment of coronary stenosis.
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