Evidence map›Paper›PMID 29566643›Full record

ArticleGenetics, selection, evolution : GSE2018

Genomic selection signatures in sheep from the Western Pyrenees.

Otsanda Ruiz-Larrañaga, Jorge Langa, Fernando Rendo, Carmen Manzano, Mikel Iriondo, Andone Estonba

Open access · goldAbstract read
In one paragraph

Article in Genetics, selection, evolution : GSE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 110 citations in OpenAlex.

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  5. Association ofPathogens (Basel, Switzerland) · 2025
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  13. Stress Factors and Their Effects on Productivity in Sheep.Animals : an open access journal from MDPI · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Otsanda Ruiz-LarrañagaGenetics, Physical Anthropology and Animal Physiology Department, University of the Basque Country (UPV/EHU), Leioa, Spain. otsanda.ruiz@ehu.eus.ORCID 0000-0002-4087-8518
Jorge LangaGenetics, Physical Anthropology and Animal Physiology Department, University of the Basque Country (UPV/EHU), Leioa, Spain.
Fernando RendoGenetics, Sequencing and Genotyping Unit, Advanced Research Facilities (SGIker), University of the Basque Country (UPV/EHU), Leioa, Spain.
Carmen ManzanoGenetics, Physical Anthropology and Animal Physiology Department, University of the Basque Country (UPV/EHU), Leioa, Spain.
Mikel IriondoGenetics, Physical Anthropology and Animal Physiology Department, University of the Basque Country (UPV/EHU), Leioa, Spain.
Andone EstonbaGenetics, Physical Anthropology and Animal Physiology Department, University of the Basque Country (UPV/EHU), Leioa, Spain.
University of the Basque Country · ES

Funding

Conservatoire des Races d'Aquitaine (CRA) US13/29University of the Basque Country (UPV/EHU) US13/29
6 · The paper itself

Abstract

backgroundThe current large spectrum of sheep phenotypic diversity results from the combined product of sheep selection for different production traits such as wool, milk and meat, and its natural adaptation to new environments. In this study, we scanned the genome of 25 Sasi Ardi and 75 Latxa sheep from the Western Pyrenees for three types of regions under selection: (1) regions underlying local adaptation of Sasi Ardi semi-feral sheep, (2) regions related to a long traditional dairy selection pressure in Latxa sheep, and (3) regions experiencing the specific effect of the modern genetic improvement program established for the Latxa breed during the last three decades.

resultsThirty-two selected candidate regions including 147 annotated genes were detected by using three statistical parameters: pooled heterozygosity H, Tajima's D, and Wright's fixation index F

conclusionsNatural and artificial selection have shaped the genome of both Sasi Ardi and Latxa sheep. Our results suggest that Sasi Ardi traits related to energy metabolism, morphological, reproductive, and immunological features have been under positive selection to adapt this semi-feral sheep to its particular environment. The highly selected Latxa sheep for dairy production showed clear signatures of selection in genomic regions related to milk production. Furthermore, our data indicate that the selection criteria applied in the modern genetic improvement program affect immunity and reproduction traits.

Indexed as

Quantitative Trait, HeritableAdaptation, BiologicalAnimalsBreedingChromosome MappingEnergy MetabolismFemaleHigh-Throughput Nucleotide SequencingLysergic Acid DiethylamideMolecular Sequence AnnotationPhenotypeSelection, GeneticSheepWhole Genome SequencingLysergic Acid DiethylamideN(1)-methyl-2-lysergic acid diethylamide

Identifiers

PMID29566643
PMCPMC5865298
OpenAlexW2800040986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.