ArticleObesity (Silver Spring, Md.)2018
Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors.
Article in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Exposure to predator threat engages sympathetic nervous system outflow to skeletal muscle.Autonomic neuroscience : basic & clinical · 2025Article
- The Bidirectional Relationship of NPY and Mitochondria in Energy Balance Regulation.Biomedicines · 2023Review
- Reduced contextually induced muscle thermogenesis in rats with calorie restriction and lower aerobic fitness but not monogenic obesity.Temperature (Austin, Tex.) · 2023Article
- Altered skeletal muscle sarco-endoplasmic reticulum CaAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Measuring Skeletal Muscle Thermogenesis in Mice and Rats.Journal of visualized experiments : JoVE · 2022Article
- Enhanced weight and fat loss from long-term intermittent fasting in obesity-prone, low-fitness rats.Physiology & behavior · 2021Article
- Skeletal muscle thermogenesis induction by exposure to predator odor.The Journal of experimental biology · 2020Article
- Caffeine enhances activity thermogenesis and energy expenditure in rats.Clinical and experimental pharmacology & physiology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveActivity thermogenesis and energy expenditure (EE) are elevated in intrinsically lean rats (high-capacity runners [HCR]) and are also stimulated by melanocortin receptor activation in the ventromedial hypothalamus (VMH). This study determined whether HCR are more responsive to central modulation of activity EE compared with low-capacity runners (LCR).
methodsHCR and LCR rats received intra-VMH microinjections of melanotan II (MTII), a mixed melanocortin receptor agonist. Changes in EE, respiratory exchange ratio, activity EE, muscle heat, norepinephrine turnover, and muscle energetic modulators were compared.
resultsHCR were significantly more responsive to intra-VMH MTII-induced changes in EE, activity EE, norepinephrine turnover to some muscle subgroups, and muscle mRNA expression of some energetic modulators. Though HCR had high muscle activity thermogenesis, limited MTII-induced modulation of muscle thermogenesis during activity was seen in LCR only.
conclusionsAn inherently lean, high-capacity rat phenotype showed elevated response to central melanocortin stimulation of activity EE and use of fat as fuel. This may be driven by sympathetic outflow to skeletal muscle, which was elevated after MTII. Central melanocortin receptor activation also altered skeletal muscle energetic modulators in a manner consistent with elevated EE and lowered respiratory exchange ratio.
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Registered trials
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