ArticlePloS one2018
Urine metabolome in women with Chlamydia trachomatis infection.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Evaluation of the Diagnostic Efficacy of Xpert CT/NG forBioMed research international · 2020Pooled it
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- Dietary habits and vaginal environment: can a beneficial impact be expected?Frontiers in cellular and infection microbiology · 2025Article
- Urinary Tract Infections Detection with Molecular Biomarkers.Biomolecules · 2024Review
- Anti-chlamydial activity of vaginal fluids: new evidence from anFrontiers in cellular and infection microbiology · 2024Article
- Feasibility of using volatile urine fingerprints for the differentiation of sexually transmitted infections.Applied microbiology and biotechnology · 2023Article
- Urine Metabolite of Mice with Orientia tsutsugamushi Infection.The American journal of tropical medicine and hygiene · 2023Article
- Exploring the metabolome of seminal plasma in two different horse types: Light versus draft stallions.Reproduction in domestic animals = Zuchthygiene · 2023Article
- Evaluation of the metabolomic profile throughScientific reports · 2022Article
- Article
- First-Void Urine Microbiome in Women withInternational journal of molecular sciences · 2022Article
- A Deep Look at the Vaginal Environment During Pregnancy and Puerperium.Frontiers in cellular and infection microbiology · 2022Article
- Are Fecal Metabolome and Microbiota Profiles Correlated with Autism Severity? A Cross-Sectional Study on ASD Preschoolers.Metabolites · 2021Article
- Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Review
- New Insights into Vaginal Environment During Pregnancy.Frontiers in molecular biosciences · 2021Article
- Vaginal metabolic profiles during pregnancy: Changes between first and second trimester.PloS one · 2021Article
- Pre-Pregnancy Diet and Vaginal Environment in Caucasian Pregnant Women: An Exploratory Study.Frontiers in molecular biosciences · 2021Article
- Metabolic profiling of Candida clinical isolates of different species and infection sources.Scientific reports · 2020Article
- Respiratory metabolites in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC) can differentiate horses affected by severe equine asthma from healthy horses.BMC veterinary research · 2020Article
- Effect of Sugars onPathogens (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to characterize the urine metabolome of women with Chlamydia trachomatis (CT) uro-genital infection (n = 21), comparing it with a group of CT-negative subjects (n = 98). By means of a proton-based nuclear magnetic resonance (1H-NMR) spectroscopy, we detected and quantified the urine metabolites of a cohort of 119 pre-menopausal Caucasian women, attending a STI Outpatients Clinic in Italy. In case of a CT positive result, CT molecular genotyping was performed by omp1 gene semi-nested PCR followed by RFLP analysis. We were able to identify several metabolites whose concentrations were significantly higher in the urine samples of CT-positive subjects, including sucrose, mannitol, pyruvate and lactate. In contrast, higher urinary levels of acetone represented the main feature of CT-negative women. These results were not influenced by the age of patients nor by the CT serovars (D, E, F, G, K) responsible of the urethral infections. Since the presence of sugars can increase the stability of chlamydial proteins, higher levels of sucrose and mannitol in the urethral lumen, related to a higher sugar consumption, could have favoured CT infection acquisition or could have been of aid for the bacterial viability. Peculiar dietary habits of the subjects enrolled, in term of type and amount of food consumed, could probably explain these findings. Lactate and pyruvate could result from CT-induced immunopathology, as a product of the inflammatory microenvironment. Further studies are needed to understand the potential role of these metabolites in the pathogenesis of CT infection, as well as their diagnostic/prognostic use.
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