ArticlePloS one2018
Cold argon-oxygen plasma species oxidize and disintegrate capsid protein of feline calicivirus.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Revealing the mechanisms of non-thermal plasma-enabled iron oxide reduction through nanoscale operando TEM.Nature communications · 2025Article
- Characterization and immunogenic evaluation of feline calicivirus epidemic strains.Journal of veterinary science · 2025Article
- Advances in Electrostatic Plasma Methods for Purification of Airborne Pathogenic Microbial Aerosols: Mechanism, Modeling and Application.Environment & health (Washington, D.C.) · 2024Review
- Plasma-activated water: Candidate hand disinfectant for SARS-CoV-2 transmission disruption.Heliyon · 2024Article
- Cold atmospheric plasma can effectively disinfect SARS-CoV-2 in the wastewater.Exploration (Beijing, China) · 2024Article
- Research Progress on Biological Accumulation, Detection and Inactivation Technologies of Norovirus in Oysters.Foods (Basel, Switzerland) · 2023Review
- Effects of non-thermal atmospheric plasma on protein.Journal of clinical biochemistry and nutrition · 2022Article
- Cold Argon Athmospheric Plasma for Biomedicine: Biological Effects, Applications and Possibilities.Antioxidants (Basel, Switzerland) · 2022Review
- Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage.Journal of hazardous materials · 2022Article
- Cold Atmospheric Plasma Ameliorates Skin Diseases Involving Reactive Oxygen/Nitrogen Species-Mediated Functions.Frontiers in immunology · 2022Review
- Inactivation of Enveloped Bovine Viral Diarrhea Virus and Non-Enveloped Porcine Parvovirus Using Low-Pressure Non-Thermal Plasma.Life (Basel, Switzerland) · 2021Article
- Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism.Biomedicines · 2021Review
- A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide.Scientific reports · 2021Article
- Inactivation of Pepper Mild Mottle Virus in Water by Cold Atmospheric Plasma.Frontiers in microbiology · 2021Article
- Virucidal Effects of Dielectric Barrier Discharge Plasma on Human Norovirus Infectivity in Fresh Oysters (Foods (Basel, Switzerland) · 2020Article
- Cold Plasma, a New Hope in the Field of Virus Inactivation.Trends in biotechnology · 2020Review
- Foodborne Viruses and Innovative Non-Thermal Food-Processing Technologies.Foods (Basel, Switzerland) · 2020Review
- Cold Atmospheric Plasma as a Novel Method for Inactivation of Potato Virus Y in Water Samples.Food and environmental virology · 2019Article
- Nitrosylation vs. oxidation - How to modulate cold physical plasmas for biological applications.PloS one · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Possible mechanisms that lead to inactivation of feline calicivirus (FCV) by cold atmospheric-pressure plasma (CAP) generated in 99% argon-1% O2 admixture were studied. We evaluated the impact of CAP exposure on the FCV viral capsid protein and RNA employing several cultural, molecular, proteomic and morphologic characteristics techniques. In the case of long exposure (2 min) to CAP, the reactive species of CAP strongly oxidized the major domains of the viral capsid protein (VP1) leading to disintegration of a majority of viral capsids. In the case of short exposure (15 s), some of the virus particles retained their capsid structure undamaged but failed to infect the host cells in vitro. In the latter virus particles, CAP exposure led to the oxidation of specific amino acids located in functional peptide residues in the P2 subdomain of the protrusion (P) domain, the dimeric interface region of VP1 dimers, and the movable hinge region linking the S and P domains. These regions of the capsid are known to play an essential role in the attachment and entry of the virus to the host cell. These observations suggest that the oxidative effect of CAP species inactivates the virus by hindering virus attachment and entry into the host cell. Furthermore, we found that the oxidative impact of plasma species led to oxidation and damage of viral RNA once it becomes unpacked due to capsid destruction. The latter effect most likely plays a secondary role in virus inactivation since the intact FCV genome is infectious even after damage to the capsid.
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