ArticleAmerican journal of public health2018
Rising Trends of Prescription Opioid Sales in Contemporary Brazil, 2009-2015.
Article in American journal of public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The Emerging Burden of Opioid Poisoning in Brazil, 2019-2025: A Nationwide Epidemiological and Toxicovigilance Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- A time-series analysis of the use of opioid medications in a network of Brazilian hospitals, 2009-2020.Lancet regional health. Americas · 2025Article
- Global, regional, and national trends and burden of opioid use disorder in individuals aged 15 years and above: 1990 to 2021 and projections to 2040.Epidemiology and psychiatric sciences · 2025Article
- Adverse Childhood Experiences in Brazilian College Students: Examining Associations with Suicidal Ideation and Risky Behaviors.Journal of child & adolescent trauma · 2024Article
- Shift in hospital opioid use during the COVID-19 pandemic in Brazil: a time-series analysis of one million prescriptions.Scientific reports · 2023Article
- Reports of rising use of fentanyl in contemporary Brazil is of concern, but a US-like crisis may still be averted.Lancet regional health. Americas · 2023Article
- Prevalence of pain and use of prescription opioids among older adults: results from the Brazilian Longitudinal Study of Aging (ELSI-Brazil).Lancet regional health. Americas · 2023Article
- Burden of disease due to amphetamines, cannabis, cocaine, and opioid use disorders in South America, 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019.The lancet. Psychiatry · 2023Article
- Reducing opioid consumption levels post-operatively following gastrointestinal surgery - A systematic review of randomized trials.Surgery in practice and science · 2022Article
- Sales of Over-the-Counter Products Containing Codeine in 31 Countries, 2013-2019: A Retrospective Observational Study.Drug safety · 2022Observational
- Responding to the opioid crisis in North America and beyond: recommendations of the Stanford-Lancet Commission.Lancet (London, England) · 2022Review
- In-hospital postoperative opioid use and its trends in neurosurgery between 2007 and 2018.Acta neurochirurgica · 2022Article
- Opioid use, regulation, and harms in Brazil: a comprehensive narrative overview of available data and indicators.Substance abuse treatment, prevention, and policy · 2021Review
- Association of sociodemographic factors with the prescription pattern of opioids for dental patients: A systematic review protocol.PloS one · 2021Article
- Non-medical use of opioid analgesics in contemporary Brazil: Findings from the 2015 Brazilian National Household Survey on Substance Use.Global public health · 2020Article
- Opioid use disorder and treatment: challenges and opportunities.BMC health services research · 2019Review
- Inappropriate opioid prescription after surgery.Lancet (London, England) · 2019Review
- World Opioid and Substance Use Epidemic: A Latin American Perspective.Psychiatric research and clinical practice · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesTo present and discuss recent patterns of prescription opioid sales throughout Brazil.
methodsWe graphed linear trends of opioid prescriptions sold from registered pharmacies across Brazil from 2009 to 2015. We then calculated the change in rate of prescriptions sold per 1000 persons in 2015 compared with 2009.
resultsOpioid sales increased across Brazil from 1 601 043 prescriptions in 2009 to 9 045 945 prescriptions in 2015, corresponding to a 465% increase in 6 years. The largest absolute increase was for codeine products (rate ratio (RR) = 5.30; 95% confidence interval [CI] = 5.29, 5.31), accounting for more than 98% of prescriptions in both years. Oxycodone had the largest relative increase (RR = 11.39; 95% CI = 11.19, 11.59), and fentanyl products had the smallest absolute and relative increase (RR = 2.91; 95% CI = 2.78, 3.03).
conclusionsGiven rapid increases in opioid sales across Brazil, it is critical to introduce effective prescribing and monitoring methods that allow patients to access necessary medications without escalating risk of opioid misuse and related consequences. Careful surveillance of supply and subsequent outcomes are needed to prevent the development of another devastating opioid epidemic in the Americas.
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