Evidence map›Paper›PMID 29565290›Full record

ReviewInternational journal of molecular sciences2018

Role of Inflammation in Diabetic Retinopathy.

Anne Rübsam, Sonia Parikh, Patrice E Fort

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 423 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
423citing papers in PubMed, 4 pooled it
56.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

423 citing papers in PubMed, 4 syntheses or guidelines pooled it, 734 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Bibliometric analysis and visualization of inflammation in the field of diabetic retinopathy research (2006-2025).Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  9. Review
  10. Article
  11. Interferon-mediated regulation of the neurovascular unit in diabetic retinopathy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  12. A case-control study of promoter and 5'UTR VEGF polymorphisms in diabetic retinopathy.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026
    Article
  13. Review
  14. Article
  15. Review
  16. Investigating the Antidiabetic Effects ofFood science & nutrition · 2026
    Article
  17. Article
  18. Review
  19. Review
  20. Review

363 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anne RübsamDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA. aruebsam@med.umich.edu.
Sonia ParikhDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA. soniapar@umich.edu.
Patrice E FortDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA. patricef@med.umich.edu.
University of Michigan–Ann Arbor · US

Funding

Progressive Impact of Diabetes on Retinal Neuroprotection by ?-CrystallinsR01EY020895 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FORT, PATRICE E. · 2012 to 2019
$3.2M
NEI NIH HHS R01 EY020895
6 · The paper itself

Abstract

Diabetic retinopathy is a common complication of diabetes and remains the leading cause of blindness among the working-age population. For decades, diabetic retinopathy was considered only a microvascular complication, but the retinal microvasculature is intimately associated with and governed by neurons and glia, which are affected even prior to clinically detectable vascular lesions. While progress has been made to improve the vascular alterations, there is still no treatment to counteract the early neuro-glial perturbations in diabetic retinopathy. Diabetes is a complex metabolic disorder, characterized by chronic hyperglycemia along with dyslipidemia, hypoinsulinemia and hypertension. Increasing evidence points to inflammation as one key player in diabetes-associated retinal perturbations, however, the exact underlying molecular mechanisms are not yet fully understood. Interlinked molecular pathways, such as oxidative stress, formation of advanced glycation end-products and increased expression of vascular endothelial growth factor have received a lot of attention as they all contribute to the inflammatory response. In the current review, we focus on the involvement of inflammation in the pathophysiology of diabetic retinopathy with special emphasis on the functional relationships between glial cells and neurons. Finally, we summarize recent advances using novel targets to inhibit inflammation in diabetic retinopathy.

Indexed as

AnimalsAstrocytesDiabetic RetinopathyEpendymoglial CellsHumansInflammationNeurodegenerative Diseasesastrocytescrystallinsdiabetic retinopathyinflammationmicrogliaMüller glial cellsneurodegenerationneuroprotectionpathophysiology

Identifiers

PMID29565290
PMCPMC5979417
OpenAlexW2793401320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.