ArticlePhysiological measurement2018
Evaluation of surrogate measures of pulmonary function derived from electrical impedance tomography data in children with cystic fibrosis.
Article in Physiological measurement, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Clinical applications of electrical impedance tomography in pediatric subjects.Pediatric research · 2026Review
- Electrical Impedance Tomography Use in Neonatal and Pediatrics Patients: A Narrative Review.Health science reports · 2025Article
- Thoracic electrical impedance tomography for assessing progression of pulmonary dysfunction in ALS.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2025Article
- Simultaneous Acquisition of EIT and ECG Signals on Active EIT Electrodes.IEEE transactions on bio-medical engineering · 2025Article
- Assessing pulmonary function in ALS using electrical impedance tomography.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2024Article
- Pulmonary rehabilitation ameliorates regional lung function in chronic obstructive pulmonary disease: a prospective single-arm clinical trial.Annals of translational medicine · 2022Article
- Improved resolution of D-bar images of ventilation using a Schur complement property and an anatomical atlas.Medical physics · 2022Article
- 3D ELECTRICAL IMPEDANCE TOMOGRAPHY RECONSTRUCTIONS FROM SIMULATED ELECTRODE DATA USING DIRECT INVERSION tInverse problems and imaging (Springfield, Mo.) · 2021Article
- Reconstruction of Organ Boundaries With Deep Learning in the D-Bar Method for Electrical Impedance Tomography.IEEE transactions on bio-medical engineering · 2021Article
- Introduction of Sample Based Prior into the D-Bar Method Through a Schur Complement Property.IEEE transactions on medical imaging · 2020Article
- A narrative review of electrical impedance tomography in lung diseases with flow limitation and hyperinflation: methodologies and applications.Annals of translational medicine · 2020Review
- The D-bar method for electrical impedance tomography-demystified.Inverse problems · 2020Article
- The ACE1 Electrical Impedance Tomography System for Thoracic Imaging.IEEE transactions on instrumentation and measurement · 2019Article
- A Review of Electrical Impedance Tomography in Lung Applications: Theory and Algorithms for Absolute Images.Annual reviews in control · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveLung function monitoring by spirometry plays a critical role in the clinical care of pediatric cystic fibrosis (CF) patients, but many young children are unable to perform spirometry, and the outputs are often normal even in the presence of lung disease. Measures derived from electrical impedance tomography (EIT) images were studied for their utility as potential surrogates for spirometry in CF patients and to assess response to intravenous antibiotic treatment for acute pulmonary exacerbations (PEx) in a subset of patients. APPROACH: EIT data were collected on 35 subjects (21 with CF, 14 healthy controls, 8 CF patients pre- and post-treatment for an acute PEx) ages 2 to 20 years during tidal breathing and also concurrently with spirometry on subjects over age 8. EIT-derived measures of FEV1, FVC, and FEV1/FVC were computed globally and regionally from dynamic EIT images. MAIN
resultsGlobal EIT-derived FEV1/FVC showed good correlation with spirometry FEV1/FVC values (r = 0.54, p = 0.01), and were able to distinguish between the groups (p = 0.01). Lung heterogeneity was assessed through the spatial coefficient of variation (CV) of EIT difference images between key time points, and the CVs for EIT-derived FEV1 and FVC showed significant correlation with the CV for tidal breathing (r = 0.47, p = 0.01 and r = 0.50, p = 0.01, respectively). Global EIT-derived FEV1/FVC was better able to distinguish between groups than spirometry FEV1 (F-values 776.5 and 146.3, respectively, p < 0.01.) The same held true for the CVs for EIT-derived FEV1, FVC, and tidal breathing (F-values 215.93, 193.89, 204.57, respectively, p < 0.01). SIGNIFICANCE: The strong correlation between the CVs for tidal breathing, FEV1, and FVC, and the statistically significant ability of CV for tidal breathing to distinguish between healthy subjects and CF patients, and between the studied CF disease states suggests that the CV may be useful for measuring the extent and severity of structural lung disease.
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