Evidence map›Paper›PMID 29565246›Full record

ArticleeLife2018

Specialized impulse conduction pathway in the alligator heart.

Bjarke Jensen, Bastiaan J Boukens, Dane A Crossley, Justin Conner, Rajiv A Mohan, Karel van Duijvenboden, Alex V Postma, Christopher R Gloschat, Ruth M Elsey, David Sedmera and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 47 citations in OpenAlex.

  1. The Interplay of Ontogeny and Phylogeny at the Transcriptome Level of the Tetrapod Heart.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025
    Article
  2. Article
  3. Review
  4. Hemodynamics During Development and Postnatal Life.Advances in experimental medicine and biology · 2024
    Review
  5. Evolutionary Aspects of Chamber Formation and Septation.Advances in experimental medicine and biology · 2024
    Review
  6. Optical mapping of contracting hearts.The Journal of physiology · 2023
    Review
  7. Avian cardiomyocyte architecture and what it reveals about the evolution of the vertebrate heart.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Development of the Cardiac Conduction System.Cold Spring Harbor perspectives in biology · 2020
    Review
  13. Cardiac Morphogenesis: Specification of the Four-Chambered Heart.Cold Spring Harbor perspectives in biology · 2020
    Review
  14. Reptiles as a Model System to Study Heart Development.Cold Spring Harbor perspectives in biology · 2020
    Review
  15. Article
  16. Article
  17. Development and evolution of the metazoan heart.Developmental dynamics : an official publication of the American Association of Anatomists · 2019
    Review
  18. Article
  19. Article
  20. Evolutionarily conservedProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Bjarke Jensen *Department of Medical Biology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-7750-8035
Bastiaan J Boukens *Department of Medical Biology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Dane A CrossleyDepartment of Biological Sciences, University of North Texas, Denton, United States.
Justin ConnerDepartment of Biological Sciences, University of North Texas, Denton, United States.
Rajiv A MohanDepartment of Medical Biology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-3622-1759
Karel van DuijvenbodenDepartment of Medical Biology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Alex V PostmaDepartment of Medical Biology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Christopher R GloschatDepartment of Biomedical Engineering, George Washington University, Washington, DC, United States.
Ruth M ElseyRockefeller Wildlife Refuge, Louisiana Department of Wildlife and Fisheries, Grand Chenier, United States.
David SedmeraInstitute of Anatomy, First Medical Faculty, Charles University, and Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
Igor R EfimovDepartment of Biomedical Engineering, George Washington University, Washington, DC, United States.ORCID http://orcid.org/0000-0002-1483-5039
Vincent M ChristoffelsDepartment of Medical Biology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4131-2636
Amsterdam UMC Location University of Amsterdam · NLGeorge Washington University · USUniversity of North Texas · USCzech Academy of Sciences · CZLouisiana Department of Wildlife and Fisheries · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammals and birds have a specialized cardiac atrioventricular conduction system enabling rapid activation of both ventricles. This system may have evolved together with high heart rates to support their endothermic state (warm-bloodedness) and is seemingly lacking in ectothermic vertebrates from which first mammals then birds independently evolved. Here, we studied the conduction system in crocodiles (

Indexed as

Alligators and CrocodilesAnimalsBundle of HisEmbryo, NonmammalianGene Expression Regulation, DevelopmentalHeartHeart Conduction SystemHeart RateHeart VentriclesIn Situ HybridizationModels, CardiovascularPurkinje FibersT-Box Domain ProteinsVentricular SeptumT-Box Domain ProteinsAmerican alligatorconduction systemdevelopmental biologyevolutionevolutionary biologygenomicsstem cellsTbx3Ventricular septum

Identifiers

PMID29565246
PMCPMC5940360
OpenAlexW2793471217

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.