ArticleAmerican journal of physiology. Lung cellular and molecular physiology2018
Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function.
Article in American journal of physiology. Lung cellular and molecular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03034642 (Modulation of Steroid Immunosuppression by Alveolar Efferocytosis), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modulation of Steroid Immunosuppression by Alveolar Efferocytosis
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Predictive value of adipokines for the severity of acute pancreatitis: a meta-analysis.BMC gastroenterology · 2024Pooled it
- Mesenteric Adipose Tissue as a Modulator of Intestinal Inflammation: Mechanistic Insights and Model Systems in Crohn's Disease.European journal of immunology · 2026Review
- Leptin as a Potential Modifier of Neuroinflammation: Contrasting Roles in Alzheimer's Disease and Multiple Sclerosis.International journal of molecular sciences · 2025Review
- Nutrition, Lifestyle, and Environmental Factors in Lung Homeostasis and Respiratory Health.Nutrients · 2025Review
- Inducible antibacterial responses in macrophages.Nature reviews. Immunology · 2025Review
- Identification and validation of key biomarkers associated with immune and oxidative stress for preeclampsia by WGCNA and machine learning.Frontiers in genetics · 2025Article
- Predictive and prognostic values of serum C1q/tumor necrosis factor-related protein 9 for first-ever ischemic stroke.Frontiers in neurology · 2025Article
- Dynamic and prognostic proteomic associations with FEVmedRxiv : the preprint server for health sciences · 2024Article
- Genetic causal role of body mass index in multiple neurological diseases.Scientific reports · 2024Article
- Ghrelin and Leptin Concentrations in Patients after SARS-CoV2 Infection.Journal of clinical medicine · 2023Article
- Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke.BMC neurology · 2022Article
- Obesity, leptin and host defence ofEuropean respiratory review : an official journal of the European Respiratory Society · 2022Review
- Influence of Nutritional Status and Physical Exercise on Immune Response in Metabolic Syndrome.Nutrients · 2022Review
- Adipose tissue macrophage in obesity-associated metabolic diseases.Frontiers in immunology · 2022Review
- Current knowledge of leptin in wound healing: A collaborative review.Frontiers in pharmacology · 2022Review
- Leptin receptor antagonist attenuates experimental autoimmune thyroiditis in mice by regulating Treg/Th17 cell differentiation.Frontiers in endocrinology · 2022Article
- Multiple sclerosis and obesity: The role of adipokines.Frontiers in immunology · 2022Review
- The Impact of Morbid Obesity on the Health Outcomes of Hospital Inpatients: An Observational Study.Journal of clinical medicine · 2021Article
- Role of myeloid cell leptin signaling in the regulation of glucose metabolism.Scientific reports · 2021Article
- Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism.Endocrine reviews · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Leptin is a pleiotropic hormone produced by white adipose tissue that regulates appetite and many physiological functions, including the immune response to infection. Genetic leptin deficiency in humans and mice impairs host defenses against respiratory tract infections. Since leptin deficiency is associated with obesity and other metabolic abnormalities, we generated mice that lack the leptin receptor (LepRb) in cells of the myeloid linage (LysM-LepRb-KO) to evaluate its impact in lean metabolically normal mice in a murine model of pneumococcal pneumonia. We observed higher lung and spleen bacterial burdens in LysM-LepRb-KO mice following an intratracheal challenge with Streptococcus pneumoniae. Although numbers of leukocytes recovered from bronchoalveolar lavage fluid did not differ between groups, we did observe higher levels of pulmonary IL-13 and TNFα in LysM-LepRb-KO mice 48 h post infection. Phagocytosis and killing of ingested S. pneumoniae were also impaired in alveolar macrophages (AMs) from LysM-LepRb-KO mice in vitro and were associated with reduced LTB
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.