Evidence map›Paper›PMID 29564865›Full record

ArticleJournal of biomedical optics2018

Multiscale optical imaging of rare-earth-doped nanocomposites in a small animal model.

Laura M Higgins, Vidya Ganapathy, Harini Kantamneni, Xinyu Zhao, Yang Sheng, Mei-Chee Tan, Charles M Roth, Richard E Riman, Prabhas V Moghe, Mark C Pierce

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Laura M HigginsRutgers, The State University of New Jersey, Department of Biomedical Engineering, Piscataway, New J, United States.
Vidya GanapathyRutgers, The State University of New Jersey, Department of Biomedical Engineering, Piscataway, New J, United States.
Harini KantamneniRutgers, The State University of New Jersey, Department of Chemical and Biochemical Engineering, Pis, United States.
Xinyu ZhaoSingapore University of Technology and Design, Engineering Product Development, Singapore.
Yang ShengSingapore University of Technology and Design, Engineering Product Development, Singapore.
Mei-Chee TanSingapore University of Technology and Design, Engineering Product Development, Singapore.
Charles M RothRutgers, The State University of New Jersey, Department of Biomedical Engineering, Piscataway, New J, United States.
Richard E RimanRutgers, The State University of New Jersey, Department of Materials Science and Engineering, Piscat, United States.
Prabhas V MogheRutgers, The State University of New Jersey, Department of Biomedical Engineering, Piscataway, New J, United States.
Mark C PierceRutgers, The State University of New Jersey, Department of Biomedical Engineering, Piscataway, New J, United States.
Rutgers, The State University of New Jersey · USSingapore University of Technology and Design · SG

Funding

Rare earth nanoprobes for optical imaging and disease tracking (C3i)R01EB018378 · NIBIB · RUTGERS, THE STATE UNIV OF N.J. · PI MOGHE, PRABHAS V, PIERCE, MARK · 2014 to 2022
$4.8M
NIBIB NIH HHS R01 EB018378
6 · The paper itself

Abstract

Rare-earth-doped nanocomposites have appealing optical properties for use as biomedical contrast agents, but few systems exist for imaging these materials. We describe the design and characterization of (i) a preclinical system for whole animal in vivo imaging and (ii) an integrated optical coherence tomography/confocal microscopy system for high-resolution imaging of ex vivo tissues. We demonstrate these systems by administering erbium-doped nanocomposites to a murine model of metastatic breast cancer. Short-wave infrared emissions were detected in vivo and in whole organ imaging ex vivo. Visible upconversion emissions and tissue autofluorescence were imaged in biopsy specimens, alongside optical coherence tomography imaging of tissue microstructure. We anticipate that this work will provide guidance for researchers seeking to image these nanomaterials across a wide range of biological models.

Indexed as

AnimalsEquipment DesignFemaleImage Processing, Computer-AssistedInfrared RaysLiverLungMetals, Rare EarthMiceMice, NudeMicroscopy, ConfocalNanocompositesOptical ImagingWhole Body ImagingMetals, Rare Earthconfocal microscopymultimodal imagingNIR-II imagingpreclinical imagingshort-wave infrared imaging

Identifiers

PMID29564865
PMCPMC5862142
OpenAlexW2789232948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.