Evidence map›Paper›PMID 29564792›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2018

Functional and Morphological Analysis of OFF Bipolar Cells.

Chase B Hellmer, Tomomi Ichinose

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Protocadherin 9 Promotes Cell Survival of Different Bipolar Cell Types in the Developing Mouse Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Impact of Photoreceptor Loss on Retinal Circuitry.Annual review of vision science · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chase B HellmerDepartments of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA.
Tomomi IchinoseDepartments of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA. tichinos@med.wayne.edu.

Funding

MECHANISMS OF TEMPORAL ENCODING IN RETINAL BIPOLAR CELLSR01EY020533 · NEI · WAYNE STATE UNIVERSITY · PI ICHINOSE, TOMOMI · 2011 to 2015
$1.8M
NEI NIH HHS R01 EY020533
6 · The paper itself

Abstract

Retinal first-order neurons, photoreceptors, receive visual inputs and convert them to neural signals. The second-order neurons, bipolar cells then sort out the visual signals and encode them through multiple neural streams. Approximately 15 morphological types of bipolar cells have been identified, which are thought to encode different aspects of visual signals such as motion and color (Ichinose et al. J Neurosci 34(26):8761-8771, 2014; Euler et al. Nat Rev Neurosci 15(8):507-519, 2014). To investigate functional aspects of OFF bipolar cells, single cell recordings are preferred; however, bipolar cells in the mouse retina are small and hard to distinguish from other types of cells. Here, we describe our methodology and tips for immunohistochemistry and patch clamp recordings for analyzing light-evoked responses in each type of OFF bipolar cell.

Indexed as

AnimalsBiotinImmunohistochemistryMembrane PotentialsMiceMicroscopy, ConfocalPatch-Clamp TechniquesPhotic StimulationRetinal Bipolar CellsBiotinneurobiotinImmunohistochemistryLight responsesNeurobiotinOFF bipolar cellsPatch clampRetinal slice preparation

Identifiers

PMID29564792
PMCPMC6291506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.