Evidence map›Paper›PMID 29564726›Full record

ArticleAnnals of intensive care2018

Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS: a secondary analysis of PRoVENT.

Fabienne D Simonis, Carmen S V Barbas, Antonio Artigas-Raventós, Jaume Canet, Rogier M Determann, James Anstey, Goran Hedenstierna, Sabrine N T Hemmes, Greet Hermans, Michael Hiesmayr and 19 more

Registry-linked trialAbstract read
In one paragraph

Article in Annals of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06288724 (Potentially MOdifiable Factors To ImproVe Outcomes of Mechanically Ventilated Patients in ICUs in a Low-income Country), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06288724 unknown statusnot on this mapstarted 2024, after this paper: background citation

Potentially MOdifiable Factors To ImproVe Outcomes of Mechanically Ventilated Patients in ICUs in a Low-income Country: Rationale and Protocol for a Registry-embedded Prospective Observational Study

Typeobservational_patient_registrySponsorNat Intensive Care Surveillance - MORURan2024 to 2024Enrolled625ConditionsCritical Illness, Invasive Mechanical Ventilation, ICU Mortality, Developing Countries
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Observational
  9. Caring for patients at risk of ARDS: the role of driving pressure.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2021
    Article
  10. Article
  11. Article
  12. Observational
  13. Review
  14. Protective mechanical ventilation in patients with risk factors for ARDS: prospective cohort study.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
    Article
  15. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Fabienne D SimonisDepartment of Intensive Care and Lab. of Experimental Intensive Care and Anesthesiology (L E I C A), Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. f.d.simonis@amc.uva.nl.
Carmen S V BarbasDepartment of Intensive Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Antonio Artigas-RaventósDepartment of Intensive Care Medicine and CIBER de Enfermedades Respiratorias, Hospital de Sabadell, Corporació Sanitaria I Universitària Parc Taulí, Sabadell, Spain.
Jaume CanetDepartment of Anesthesiology, Hospital Universitari Germans Trias I Pujol, Barcelona, Spain.
Rogier M DetermannDepartment of Critical Care, Westfriesgasthuis, Hoorn, The Netherlands.
James AnsteyDepartment of Intensive Care, St Vincent's Hospital, Melbourne, Australia.
Goran HedenstiernaDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Sabrine N T HemmesDepartment of Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands.
Greet HermansMedical Intensive Care Unit, Division of General Internal Medicine, University Hospital Leuven, Louvain, Belgium.
Michael HiesmayrDivision of Cardiac, Thoracic, and Vascular Anesthesia and Intensive Care, Medical University Vienna, Vienna, Austria.
Markus W HollmannDepartment of Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands.
Samir JaberDepartment of Critical Care Medicine and Anesthesiology (SAR B), Saint Eloi University Hospital, Montpellier, France.
Ignacio Martin-LoechesDepartment of Clinical Medicine, Trinity Centre for Health Sciences, Multidisciplinary Intensive Care Research Organization (MICRO), Welcome Trust, HRB Clinical Research, St James's University Hospital Dublin, Dublin, Ireland.
Gary H MillsDepartment of Anaesthesia and Critical Care Medicine, Sheffield Teaching Hospital, Sheffield, UK.
Rupert M PearseBarts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Christian PutensenDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
Werner SchmidDivision of Cardiac, Thoracic, and Vascular Anesthesia and Intensive Care, Medical University Vienna, Vienna, Austria.
Paolo SevergniniDepartment of Biotechnologies and Sciences of Life, Insubria University, Varese, Italy.
Roger SmithDepartment of Intensive Care, St Vincent's Hospital, Melbourne, Australia.
Tanja A TreschanDepartment of Anaesthesiology, Düsseldorf University Hospital, Düsseldorf, Germany.
Edda M TschernkoDivision of Cardiac, Thoracic, and Vascular Anesthesia and Intensive Care, Medical University Vienna, Vienna, Austria.
Marcos F Vidal MeloDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Hermann WriggeDepartment of Anesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig, Germany.
Marcelo Gama de AbreuPulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Dresden, Germany.
Paolo PelosiDepartment of Surgical Sciences and Integrated Diagnostics, Ospedale Policlinico per la Oncologia, IRCCS per l'Oncologia, University of Genoa, Genoa, Italy.
Marcus J SchultzDepartment of Intensive Care and Lab. of Experimental Intensive Care and Anesthesiology (L E I C A), Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Ary Serpa NetoDepartment of Intensive Care and Lab. of Experimental Intensive Care and Anesthesiology (L E I C A), Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
PRoVENT investigators
PROVE Network investigators

Funding

Regional Tidal Lung Strain and Neutrophilic Inflammation in Early Lung InjuryR01HL121228 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI VIDAL MELO, MARCOS F · 2014 to 2023
$6.2M
Intraoperative Protective Ventilation and Postoperative Pulmonary ComplicationsR34HL123438 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI VIDAL MELO, MARCOS F · 2015 to 2017
$599k
NHLBI NIH HHS R01 HL121228NHLBI NIH HHS R34 HL123438
6 · The paper itself

Abstract

backgroundThe majority of critically ill patients do not suffer from acute respiratory distress syndrome (ARDS). To improve the treatment of these patients, we aimed to identify potentially modifiable factors associated with outcome of these patients.

methodsThe PRoVENT was an international, multicenter, prospective cohort study of consecutive patients under invasive mechanical ventilatory support. A predefined secondary analysis was to examine factors associated with mortality. The primary endpoint was all-cause in-hospital mortality.

results935 Patients were included. In-hospital mortality was 21%. Compared to patients who died, patients who survived had a lower risk of ARDS according to the 'Lung Injury Prediction Score' and received lower maximum airway pressure (P

conclusionsHigher P

Indexed as

Mechanical ventilationMortalityOutcomeVentilator settings

Identifiers

PMID29564726
PMCPMC5862714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.