Evidence map›Paper›PMID 29564671›Full record

Observational studyDigestive diseases and sciences2018

Role of Positron Emission Tomography in Assessing Disease Activity in Ulcerative Colitis: Comparison with Biomarkers.

Neha Berry, Saroj Kant Sinha, Anish Bhattacharya, K K Prasad, Chetana Vaishnavi, Kim Vaiphei, Jayanta Samanta, Raghavendra Prasada, Narendra Dhaka, Rakesh Kochhar

Abstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Comparison ofThe British journal of radiology · 2020
    Trial
  2. Hybrid Molecular Imaging Using PET/CT and PET/MRI in Inflammatory Bowel Disease: Current Applications, Challenges, and Future Perspectives.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  3. Article
  4. Review
  5. Diagnostic Performance of Simultaneous [Journal of clinical medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Neha BerryDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
Saroj Kant SinhaDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India. sarojksinha@hotmail.com.
Anish BhattacharyaDepartment of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
K K PrasadDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
Chetana VaishnaviDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
Kim VaipheiDepartment of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Jayanta SamantaDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
Raghavendra PrasadaDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
Narendra DhakaDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
Rakesh KochharDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisease activity in ulcerative colitis (UC) is best assessed clinically by Mayo score. 18-Fluorodeoxyglucose positron emission tomography-computerized tomography (FDG PET-CT) is a noninvasive imaging technique to assess extent, disease activity and response to treatment of UC, especially in high risk population or patients unwilling for endoscopy.

aimsWe conducted a prospective observational study with the aim of assessing and correlating UC disease activity by clinical criteria, endoscopy, histology, serum and fecal biomarkers, and FDG PET-CT.

methodsSixty eligible patients of UC were enrolled into three groups (26 remission, 24 moderate and 10 severe activity) as per Mayo score and FDG PET-CT was performed within 72 h of colonoscopy. ESR, CRP, and fecal calprotectin (FC) levels were determined for all patients.

resultsOf 60 enrolled patients, 10% patients had proctitis, 43.3% left-sided colitis, and 46.7% extensive colitis. ESR, CRP, FC levels, and rectal PET activity were significantly higher in groups with moderate and severe disease activity. Rectal PET activity showed a significant correlation with the Mayo score (k = 0.465, p < 0.001), endoscopic subscore (k = 0.526, p < 0.001), histological score (k = 0.496, p < 0.001), and FC (k = 0.279, p = 0.031). Extent evaluation by FDG PET-CT and colonoscopy showed a significant correlation (k = 0.582, p < 0.001). Besides, FDG PET-CT identified sacroiliitis in one patient and adenocarcinoma in one patient.

conclusionFDG PET-CT is a reliable noninvasive tool for detection of disease activity, extent in UC with good correlation with Mayo score, histology and fecal biomarkers and accurate predictor of disease remission.

Indexed as

Positron Emission Tomography Computed TomographyAdultBiomarkersBlood SedimentationColitis, UlcerativeColonColonoscopyC-Reactive ProteinFecesFemaleFluorodeoxyglucose F18HumansLeukocyte L1 Antigen ComplexMaleMiddle AgedPredictive Value of TestsBiomarkersC-Reactive ProteinFluorodeoxyglucose F18Leukocyte L1 Antigen ComplexRadiopharmaceuticalsEndoscopyFecal calprotectinPositron emission tomographyUlcerative colitis

Identifiers

PMID29564671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.