Evidence map›Paper›PMID 29564621›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018

Addition of doxycycline to ciprofloxacin for infection prophylaxis during autologous stem cell transplants for multiple myeloma.

J M Sivik, J Davidson, C M Hale, J J Drabick, G Talamo

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

J M SivikDepartment of Pharmacy, Penn State Health-M.S. Hershey Medical Center, Hershey, PA, USA. jsivik@pennstatehealth.psu.edu.ORCID http://orcid.org/0000-0002-3259-1584
J DavidsonDepartment of Medicine, Hematology/Oncology Division, Penn State College of Medicine, Hershey, PA, USA.
C M HaleDepartment of Pharmacy, Penn State Health-M.S. Hershey Medical Center, Hershey, PA, USA.
J J DrabickDepartment of Medicine, Hematology/Oncology Division, Penn State College of Medicine, Hershey, PA, USA.
G TalamoDepartment of Medicine, Hematology/Oncology Division, Penn State College of Medicine, Hershey, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe most commonly used antibacterial prophylaxis during autologous stem cell transplants (ASCT) for multiple myeloma (MM) involves a fluoroquinolone, such as ciprofloxacin or levofloxacin. We assessed the impact of adding doxycycline to ciprofloxacin as routine antibacterial prophylaxis in these patients.

methodsWe retrospectively reviewed electronic medical records and our ASCT database to analyze rates and types of bacterial infections in MM patients who underwent ASCT in our institution.

resultsAmong 419 patients, 118 received ciprofloxacin alone (cipro group), and 301 ciprofloxacin and doxycycline (cipro-doxy group). Neutropenic fever (NF) developed in 63 (53%) and 108 (36%) patients of the cipro and cipro-doxy groups, respectively (p = 0.010). The number of documented bacteremic episodes was 13 (11%) and 14 (4.7%) in the two groups, respectively (p = 0.017). Antimicrobial resistance and Clostridium difficile infections were uncommon. Transplant-related mortality was 1% in both groups.

conclusionsThe addition of doxycycline to standard prophylaxis with ciprofloxacin seems to reduce the number of NF episodes and documented bacterial infections in patients with MM undergoing ASCT, without increasing rate of serious complications.

Indexed as

AdultAgedAnti-Bacterial AgentsBacterial InfectionsCiprofloxacinDoxycyclineFemaleHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedMultiple MyelomaRetrospective StudiesTransplantation, AutologousAnti-Bacterial AgentsCiprofloxacinDoxycyclineAutologous stem cell transplantDoxycyclineHigh-dose melphalanInfection prophylaxisMultiple myeloma

Identifiers

PMID29564621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.