ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2018
The effect of late radiotherapy on the progression of heterotopic ossification following total hip arthroplasty.
Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Effectiveness of Radiotherapy in Preventing Heterotopic Ossification: A Meta-analysis of Randomized Controlled Trials Beyond Total Hip Arthroplasty.Calcified tissue international · 2025Pooled it
- Fifteen years' experience of radiation therapy for resected advanced heterotopic ossification following motor vehicle accidents: outcome and side effects.Journal of the Egyptian National Cancer Institute · 2022Article
- Radiation therapy for the prevention of heterotopic ossification: Efficacy and toxicity of single fraction radiotherapy.Orthopedic reviews · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHeterotopic ossification (HO) is a known complication after total hip arthroplasty (THA). Radiotherapy is an effective prophylactic treatment for high-risk patients. However, there is no treatment for patients who did not receive prophylactic treatment and subsequently develop HO postoperatively. This study was to determine whether late radiotherapy treatment can prevent the progression of HO following THA.
methodsA chart review was performed to identify patients who developed HO following THA and were treated with late radiotherapy. All these patients received radiotherapy after their 6- or 12-week postoperative follow-up. Patients were evaluated radiographically pre- and 2 years post-radiotherapy using ImageJ software to measure the difference in the area of HO that formed.
resultsNine patients with a mean age of 64.5 years were identified. All patients developed HO within 6- or 12-week postsurgery and received later radiotherapy. Eight of the nine hips (89%) treated with late radiotherapy demonstrated no further progression in the amount of bone formed. Overall, there was an increase in the mean total area of HO by 19 mm
conclusionLate, low-dose radiotherapy is effective in preventing the progression of HO in patients who unexpectedly develop significant HO following THA.
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