Evidence map›Paper›PMID 29564580›Full record

ArticleJournal of biomolecular NMR2018

Trimethylsilyl tag for probing protein-ligand interactions by NMR.

Walter Becker, Luke A Adams, Bim Graham, Gabriel E Wagner, Klaus Zangger, Gottfried Otting, Christoph Nitsche

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of biomolecular NMR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Walter BeckerResearch School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.
Luke A AdamsMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Bim GrahamMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Gabriel E WagnerInstitute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, 8010, Graz, Austria.
Klaus ZanggerInstitute of Chemistry, University of Graz, 8010, Graz, Austria.
Gottfried OttingResearch School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.ORCID 0000-0002-0563-0146
Christoph NitscheResearch School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia. christoph.nitsche@anu.edu.au.ORCID 0000-0002-3704-2699
Australian National University · AUMonash University · AUMedical University of Graz · ATUniversity of Graz · AT

Funding

Australian Research Council FL170100019Austrian Science Fund W901
6 · The paper itself

Abstract

Protein-ligand titrations can readily be monitored with a trimethylsilyl (TMS) tag. Owing to the intensity, narrow line shape and unique chemical shift of a TMS group, dissociation constants can be determined from straightforward 1D

Indexed as

HumansLigandsMolecular ProbesNuclear Magnetic Resonance, BiomolecularPeptide HydrolasesProtein BindingProteinsSilanesTacrolimus Binding ProteinsViral ProteinsZika VirusLigandsMolecular ProbesPeptide HydrolasesProteinsSilanesTacrolimus Binding ProteinstriethylsilaneViral ProteinsDissociation constantLead discoveryProtein–ligand interactionsSlow exchangeTrimethylsilyl group

Identifiers

PMID29564580
OpenAlexW2789700978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.