Evidence map›Paper›PMID 29564561›Full record

ArticleMedical molecular morphology2018

Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs.

Yoshihito Nakagawa, Yukihiro Akao, Tomomitsu Tahara, Hiromi Yamashita, Mitsuo Nagasaka, Tomoyuki Shibata, Naoki Ohmiya

Abstract read
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Article in Medical molecular morphology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yoshihito NakagawaDepartment of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan. yo-hi@fujita-hu.ac.jp.ORCID http://orcid.org/0000-0001-8689-492X
Yukihiro AkaoThe United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, 501-1193, Japan.
Tomomitsu TaharaDepartment of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Hiromi YamashitaDepartment of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Mitsuo NagasakaDepartment of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Tomoyuki ShibataDepartment of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Naoki OhmiyaDepartment of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Fujita Health University · JPGifu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P). We tried to clarify the relationship between the expression of the miRNAs and the colorectal tumor development. The expression levels of miR-143, -145, and -34a were reduced in most of the polypoid and FAP tumors compared with those in the flat elevated, UCAT, SSA/P ones. In type 2 adenocarcinomas, the expression profile of these miRNAs was similar to those of the polypoid and FAP tumors. The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors. These findings indicated that the expression of onco-related miRNAs was closely associated with the development and endoscopic appearance of colorectal tumors.

Indexed as

Gene Expression Regulation, NeoplasticMicroRNAsAdenocarcinomaAdenomaAdenomatous Polyposis ColiColorectal NeoplasmsEndoscopy, GastrointestinalHumansMicroRNAsAdenoma–carcinoma sequenceColorectal tumor developmentFlat elevated tumorOnco-related microRNASessile serrated adenoma/polypUlcerative colitis-associated tumor

Identifiers

PMID29564561
OpenAlexW2794060475

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.