Evidence map›Paper›PMID 29564487›Full record

ArticleMicrobial ecology2018

Gut Microbial Dysbiosis in Indian Children with Autism Spectrum Disorders.

Joby Pulikkan, Abhijit Maji, Darshan Bharat Dhakan, Rituja Saxena, Binoop Mohan, Milu Maria Anto, Neeti Agarwal, Tony Grace, Vineet K Sharma

Abstract read
PubMed Publisher
In one paragraph

Article in Microbial ecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 16 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 16 syntheses or guidelines pooled it, 181 citations in OpenAlex.

  1. Global Microbiome: Core and Unique Signatures Across Diverse Populations.International journal of molecular sciences · 2026
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  6. Microbiota in Autism Spectrum Disorder: A Systematic Review.International journal of molecular sciences · 2023
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Joby PulikkanDepartment of Genomic Science, Central University of Kerala, Kasaragod, India.
Abhijit MajiMetagenomics and Systems Biology Group, Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, India.
Darshan Bharat DhakanMetagenomics and Systems Biology Group, Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, India.
Rituja SaxenaMetagenomics and Systems Biology Group, Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, India.
Binoop MohanDepartment of Genomic Science, Central University of Kerala, Kasaragod, India.
Milu Maria AntoDepartment of Psychology, Prajyoti Niketan College, Pudukad, Kerala, India.
Neeti AgarwalDepartment of Paediatrics and Neurology, Mahaveer Institute of Medical Science, Bhopal, India.
Tony GraceDepartment of Genomic Science, Central University of Kerala, Kasaragod, India. tonygrace@cukerala.ac.in.
Vineet K SharmaMetagenomics and Systems Biology Group, Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, India. vineetks@iiserb.ac.in.
Indian Institute of Science Education and Research, Bhopal · INCentral University of Kerala · INKansas State University · USThe Sanskrit College and University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a term associated with a group of neurodevelopmental disorders. The etiology of ASD is not yet completely understood; however, a disorder in the gut-brain axis is emerging as a prominent factor leading to autism. To identify the taxonomic composition and markers associated with ASD, we compared the fecal microbiota of 30 ASD children diagnosed using Childhood Autism Rating Scale (CARS) score, DSM-5 approved AIIMS-modified INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD), and Indian Scale for Assessment of Autism (ISAA) tool, with family-matched 24 healthy children from Indian population using next-generation sequencing (NGS) of 16S rRNA gene amplicon. Our study showed prominent dysbiosis in the gut microbiome of ASD children, with higher relative abundances of families Lactobacillaceae, Bifidobacteraceae, and Veillonellaceae, whereas the gut microbiome of healthy children was dominated by the family Prevotellaceae. Comparative meta-analysis with a publicly available dataset from the US population consisting of 20 ASD and 20 healthy control samples from children of similar age, revealed a significantly high abundance of genus Lactobacillus in ASD children from both the populations. The results reveal the microbial dysbiosis and an association of selected Lactobacillus species with the gut microbiome of ASD children.

Indexed as

Gastrointestinal MicrobiomeAdolescentAutism Spectrum DisorderBacteriaBiomarkersChildChild, PreschoolDNA, BacterialDysbiosisFecesFemaleHumansIndiaMaleRNA, Ribosomal, 16SSequence Analysis, RNABiomarkersDNA, BacterialRNA, Ribosomal, 16SAutism spectrum disorder (ASD)Gastrointestinal symptomsGut-brain axisGut microbial dysbiosisIndian children

Identifiers

PMID29564487
OpenAlexW2789794205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.