ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018
Population-based study of age- and sex-related differences in muscle density and size in thoracic and lumbar spine: the Framingham study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 62 citations in OpenAlex.
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- Thoracic Skeletal Muscle Attenuation Predicts Sex-Specific Mortality After Coronary Artery Bypass Grafting-Sex-Specific Insights into Risk Stratification and Frailty Assessment.Medical sciences (Basel, Switzerland) · 2026Article
- Deep learning-based quantification of muscle volume and attenuation and their associations with preinjury ambulatory status in patients with hip fractures.Osteoporosis and sarcopenia · 2026Article
- Reference values and cut-points for trunk myopenia and myosteatosis in Chinese adults: a secondary analysis of the China Action on Spine and Hip study.Quantitative imaging in medicine and surgery · 2026Article
- Association of trabecular texture and paraspinal muscle characteristics with prevalent vertebral fractures - QCT results from a subcohort of the AGES population.BMC musculoskeletal disorders · 2026Article
- Metastatic Spine Disease Alters Vertebral Load-To-Strength Ratios in Cancer Patients Compared to Healthy Individuals.JOR spine · 2026Article
- Relationship between Trunk Muscle Fat Infiltration and Aspiration Pneumonia after Hip Fracture in Older Women: An Exploratory Study.Physical therapy research · 2026Article
- Myosteatosis: an emerging biomarker of aging.Frontiers in aging · 2026Review
- Association of the skeletal muscle mass to visceral fat area ratio with metabolically healthy obesity and metabolically unhealthy non-obesity: a cross-sectional study based on NHANES 2011-2018.Lipids in health and disease · 2025Article
- Impact of Trunk Versus Skeletal Muscle Mass Gain on Balance Improvement in Patients with Cerebral Infarction.JMA journal · 2025Article
- Reference Data and Predictors of HR-pQCT-Derived Muscle Density and Its Prediction of Physical Performance.Journal of cachexia, sarcopenia and muscle · 2025Article
- Age- and sex-specific relationships between bone mineral density, abdominal fat, and paravertebral muscle.Scientific reports · 2025Article
- Evaluation of Attenuation of Lumbar Epaxial Musculature in Dogs with Spinal Pathology.Animals : an open access journal from MDPI · 2025Article
- Risk factors and foot biomechanical characteristics of idiopathic scoliosis: a cross-sectional study.Scientific reports · 2025Article
- Exploring the Relationship Between Low Back Pain, Physical Activity, Posture, and Body Composition in Older Women.Healthcare (Basel, Switzerland) · 2025Article
- Variations of QCT-based abdominal and paravertebral muscle tissue content by age and gender.BMC musculoskeletal disorders · 2025Article
- The effect of a soft active back support exosuit on trunk motion and thoracolumbar spine loading during squat and stoop lifts.Ergonomics · 2025Article
- Automated segmentation of trunk musculature with a deep CNN trained from sparse annotations in radiation therapy patients with metastatic spine disease: an observational study.Frontiers in bioengineering and biotechnology · 2025Article
- A Respiratory Sensor-Based Study of the Relationship between Voluntary Breathing Patterns and Aerobic and Anerobic Exercise Capacity-An Exploratory Applied Study.Sensors (Basel, Switzerland) · 2024Article
- In reply to RMED-D-24-00123.Japanese journal of radiology · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Relative age-related deficit in trunk muscle density was greater in women than men whereas the relative decrease in muscle mass with age was similar in both sexes. The greater muscle fat content and greater age-related fat accumulation among women may contribute to women suffering more functional disabilities than men.
introductionA better understanding of the effect of aging on trunk musculature will have implications for physical function, disability, pain, and risk of injury in older adults. Thus, we determined the age- and sex-related differences in muscle density and size of both thoracic and lumbar trunk muscles.
methodsIn this cross-sectional study, muscle density and size were measured from quantitative computed tomography (QCT) scans for 10 trunk muscle groups at different vertebral levels in 250 community-based men and women aged 40 to 90 years from the Framingham Offspring and Third Generation cohorts.
resultsTrunk muscles in men were 20-67% larger and had 5-68% higher density than in women. The relative age-related deficits in muscle size were similar in both sexes, and decreased on average by ~ 8% per decade in both sexes. In contrast, women had greater age-related decreases in muscle density than men (- 17% in women, and - 11% in men, p < 0.01). Age-related declines varied by specific muscle, tending to be greater for outer trunk muscles than for paraspinal muscles, but within a given muscle the age-related changes in muscle density and size were similar among spinal levels.
conclusionThis comprehensive study of trunk muscle deficits with increasing age may have important implications for physical function, disability, pain, and risk of injury in older adults. The greater levels of mobility impairments with aging in women may in part be explained by greater proportion of intramuscular fat tissue and greater age-related fat accumulation in trunk muscles in women than in men.
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