ArticleEJNMMI radiopharmacy and chemistry2017
Improved radiolabeling of DOTATOC with trivalent radiometals for clinical application by addition of ethanol.
Article in EJNMMI radiopharmacy and chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
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- Production of GMP-Compliant Clinical Amounts of Copper-61 Radiopharmaceuticals from Liquid Targets.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine.Molecules (Basel, Switzerland) · 2022Review
- Optimization of Precursor Preparation in PSMA-11 Radiolabeling to Obtain a Highly Reproducible Radiochemical Yield.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Development and Validation of an Analytical HPLC Method to Assess Chemical and Radiochemical Purity of [Molecules (Basel, Switzerland) · 2022Article
- Article
- Synthesis and evaluation of radiogallium-labeled long-chain fatty acid derivatives as myocardial metabolic imaging agents.PloS one · 2021Article
- A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies withMolecules (Basel, Switzerland) · 2020Review
- Ethanol effects onEJNMMI radiopharmacy and chemistry · 2019Article
- Evaluation of polydentate picolinic acid chelating ligands and an α-melanocyte-stimulating hormone derivative for targeted alpha therapy using ISOL-producedEJNMMI radiopharmacy and chemistry · 2019Article
- Erratum: Publisher Correction toEJNMMI radiopharmacy and chemistry · 2018Article
- Improved Efficacy of Synthesizing *MInorganic chemistry · 2018Article
- Somatostatin receptor based PET/CT in patients with the suspicion of cardiac sarcoidosis: an initial comparison to cardiac MRI.Oncotarget · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTypically, metal-based radiopharmaceuticals are synthesized in aqueous solutions with no or low ethanol content. Labeling yields are defined by temperature, period of labeling, amount of precursor, pH etc. As recently observed, radiolabeling yields (RCY) seem to increase in the presence of non-aqueous solvents. Consequently, this effect was investigated systematically using ethanol as non-aqueous solvent (n-as), which is widely utilized in medicine, and DOTATOC as model compound.
methodsTo determine the impact of ethanol on the radiolabeling efficacy, "standard" labeling conditions of
resultsFor increasing amounts of ethanol,
conclusionThere is clear experimental evidence, that adding more than 20 vol% ethanol to the reaction mixtures significantly improve labeling efficacies. This could be demonstrated for
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