Article3 Biotech2018
Modelling of some aspects of a biomedical process: application to the treatment of digestive cancer (HIPEC).
Article in 3 Biotech, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05426928 (Development of a Computational, Thermodynamic Model of Intraabdominal Hyperthermia in Humans Undergoing HIPEC), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of a Computational, Thermodynamic Model of Intraabdominal Hyperthermia in Humans Undergoing HIPEC
Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- The Role of Hyperthermia in the Treatment of Peritoneal Surface Malignancies.Current oncology reports · 2022Review
- Temperature management during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.Frontiers in oncology · 2022Review
- Heating technology for malignant tumors: a review.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Usual therapies against malignant tumors, such as surgery, chemotherapy, radiation, is severe and when repeated their efficiency may decrease because tumorous cells may become resistant. Contrarily, hyperthermia has been known for some time as an effective auxiliary treatment, which can be applied repeatedly. In some cases of abdominal carcinomatosis, particularly those of digestive origin, HIPEC is considered as an promising therapeutic option. Chemotherapy and hyperthermia are combined via the perfusion of the abdominal cavity with hot fluids containing chemotherapeutic agents, thus, augmenting the influence of appropriate chemotherapeutic agents with heat. The paper deals with in vivo temperature measurements during the treatment and the identification and development of a heat transfer model of the treatment and consequently its optimization. First, the focus is on in vivo acquisition and monitoring of temperatures. Temperature probe characteristics are identified. Next, a dynamic model for the heat transfer in the patient's body during the HIPEC is outlined. Then model is validated using experimental data collected by the medical partners (St-Etienne Bellevue and Lyon-Sud, France) during in vivo HIPEC. Finally, the concluding comments are reported, including the current perspectives. Since the effectiveness of HIPEC is based on the achievement of a uniform hyperthermic intracavity temperature, properly modelling and developing supervising/monitoring methods for heat transfer for this procedure is the motivation for this research. The paper presents some preliminary groundwork for an eventual simulator and decision aid related to HIPEC.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.