Evidence map›Paper›PMID 29564173›Full record

ArticleJournal of gastrointestinal oncology2018

Complete pathologic response is independent of the timing of esophagectomy following neoadjuvant chemoradiation for esophageal cancer.

Smit Singla, Emmanuel Gabriel, Raed Alnaji, William Du, Kristopher Attwood, Hector Nava, Steven N Hochwald, Moshim Kukar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Smit SinglaDepartment of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Emmanuel GabrielDepartment of Surgery, Section of Surgical Oncology, Mayo Clinic, Jacksonville, FL, USA.
Raed AlnajiDepartment of Medicine, University of Buffalo Medical School, Buffalo, NY, USA.
William DuDepartment of Medicine, University of Buffalo Medical School, Buffalo, NY, USA.
Kristopher AttwoodDepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY, USA.
Hector NavaDepartment of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Steven N HochwaldDepartment of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Moshim KukarDepartment of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
NCI NIH HHS P30 CA016056
6 · The paper itself

Abstract

backgroundThe relationship of complete pathologic response (cPR) with the timing of esophagectomy after neoadjuvant chemoradiation (nCRT) is not well defined. We sought to determine if a delay in esophagectomy after nCRT would result in increased likelihood of cPR and improved survival.

methodsThis is a retrospective analysis of a prospectively maintained database of all patients treated with nCRT and esophagectomy between 2004 and 2014. Patients were divided into two groups based on timing of esophagectomy (≤50

resultsThis study included 226 patients (males, 211 and median age, 61 years) for analysis. Fifty-two patients (23%) in the early group (≤50 days) were compared to 174 patients (77%) in the delayed group (>50 days). The two groups were similar with respect to age, gender, comorbid conditions, ECOG status, location, grade, and tumor histology. There was no statistically significant difference in cPR rate between the early and late groups (26.9%

conclusionsThis analysis of a large cohort of patients with esophageal cancer undergoing multi-modality therapy shows that cPR is independent of the timing of esophagectomy. Other considerations for the timing of surgery, including recovery from nCRT and patient performance, may have more relevant roles than cPR when deciding when to perform esophagectomy.

Indexed as

esophageal adenocarcinomaesophageal cancersEsophageal cancer surgery

Identifiers

PMID29564173
PMCPMC5848031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.