ArticleClinical epidemiology2018
Acetaminophen administration and the risk of acute kidney injury: a self-controlled case series study.
Article in Clinical epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Association of early acetaminophen administration with mortality among critically ill patients with ischemic stroke: a retrospective cohort study.BMC neurology · 2026Article
- Early acetaminophen Use and 90-day mortality in ICU patients with ischemic stroke.Frontiers in pharmacology · 2025Article
- Efficacy of Multimodal Analgesia with Transversus Abdominis Plane Block in Comparison with Intrathecal Morphine and Intravenous Patient-Controlled Analgesia after Robot-Assisted Laparoscopic Partial Nephrectomy.Journal of clinical medicine · 2024Article
- Article
- Evaluation of the effect of managing oxycodone/acetaminophen as a psychotropic medicine: An interrupted time-series study.Frontiers in pharmacology · 2023Article
- An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact.Journal of pain research · 2023Review
- Potential therapeutic effects of Chinese meteria medica in mitigating drug-induced acute kidney injury.Frontiers in pharmacology · 2023Review
- Use of proton pump inhibitors and macrolide antibiotics and risk of acute kidney injury: a self-controlled case series study.BMC nephrology · 2022Article
- Protective Effects of Polydatin from Grapes andNutrients · 2022Article
- Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract ofBioMed research international · 2022Article
- Pharmacoepidemiology for nephrologists (part 1): concept, applications and considerations for study design.Clinical kidney journal · 2021Review
- Influence of acetaminophen on renal function: a longitudinal descriptive study using a real-world database.International urology and nephrology · 2021Article
- Roles of Hydrogen Sulfide Donors in Common Kidney Diseases.Frontiers in pharmacology · 2020Review
- [Treatment of rheumatic disease with renal insufficiency].Der Orthopade · 2019Review
- Effects of hydrogen sulfide on acetaminophen-induced acute renal toxicity in rats.International urology and nephrology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcetaminophen (APAP) is frequently used for analgesia and is considered safer than nonsteroidal anti-inflammatory drugs (NSAIDs) for the kidneys. However, there is little epidemiological evidence of the association between APAP and acute kidney injury (AKI).
objectivesTo examine the association between APAP and AKI using the self-controlled case series (SCCS) method, which is a novel strategy to control between-person confounders by comparing the risk and reference periods in each patient.
methodsWe performed SCCS in 1,871 patients (39.9% female) who were administered APAP and subsequently developed AKI, by reviewing electronically stored hospital information system data from May 2011 to July 2016. We used conditional Poisson regression to compare each patient's risk and reference period. As a time-varying confounder, we adjusted the status of liver and kidney functions, systemic inflammation, and exposure to NSAIDs.
resultsWe identified 5,650 AKI events during the 260,549 person-day observation period. The unadjusted incidences during the reference and exposure periods were 2.01/100 and 3.12/100 person-days, respectively. The incidence rate ratio adjusted with SCCS was 1.03 (95% confidence interval [CI]: 0.95-1.12). When we restricted endpoints as stage 2 AKI- and stage 3 AKI-level creatinine elevations, the incidence rate ratios were 1.20 (95% CI 0.91-1.58) and 1.20 (95% CI 0.62-2.31), respectively, neither of which was statistically significant.
conclusionOur findings added epidemiological information for the relationship between APAP administration and AKI development. The results indicated scarce association between APAP and AKI, presumably supporting the general physicians' impression that APAP is safer for kidney.
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