ArticleInternational journal of nanomedicine2018
Pomegranate extract-loaded solid lipid nanoparticles: design, optimization, and in vitro cytotoxicity study.
Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Clinical comparative study of optimized metronidazole loaded lipid nanocarrier vaginal emulgel for management of bacterial vaginosis and its recurrence.Drug delivery · 2021Trial
- Tucuma Fat-Based Nanostructured Lipid Carriers: Physical Stability and Antifungal Activity.ACS omega · 2026Article
- Development and optimization of Moxifloxacin solid lipid nanoparticles via double emulsion organic solvent free technique applying Box-Behnken experimental design.Scientific reports · 2025Article
- FeACS omega · 2025Article
- SLNs and NLCs for Skin Applications: Enhancing the Bioavailability of Natural Bioactives.Pharmaceutics · 2024Review
- Review
- Resolving acne with optimized adapalene microspongeal gel, in vivo and clinical evaluations.Scientific reports · 2024Article
- Delivery of Avocado Seed Extract Using Novel Charge-Switchable Mesoporous Silica Nanoparticles with Galactose Surface Modified to Target Sorafenib-Resistant Hepatocellular Carcinoma.International journal of nanomedicine · 2024Article
- Antitumoral properties of the pomegranate peel and blueberry extracts against tongue carcinoma (The Saudi dental journal · 2023Article
- Review
- Chitosan-Coated SLN: A Potential System for Ocular Delivery of Metronidazole.Pharmaceutics · 2023Article
- Unroasted Green Coffee Extract-Loaded Solid Lipid Nanoparticles for Enhancing Intestinal Permeation.ACS omega · 2023Article
- Green Extraction of Annatto Seed Oily Extract and Its Use as a Pharmaceutical Material for the Production of Lipid Nanoparticles.Molecules (Basel, Switzerland) · 2022Article
- Nanomedicine-Based Delivery Strategies for Breast Cancer Treatment and Management.International journal of molecular sciences · 2022Review
- Role of Solid Lipid Nanoparticles for the Delivery of Lipophilic Drugs and Herbal Medicines in the Treatment of Pulmonary Hypertension.Pharmaceutical nanotechnology · 2022Review
- Enhanced Bioactivity of Pomegranate Peel Extract following Controlled Release from CaCOBioinorganic chemistry and applications · 2022Article
- Receptor-Mediated Targeting in Breast Cancer through Solid Lipid Nanoparticles and Its Mechanism.Current drug metabolism · 2022Review
- Screening of Adapalene Microsponges Fabrication Parameters with Insight on the In vitro Biological Effectiveness.Drug design, development and therapy · 2022Article
- Polyphenols as Antioxidants for Extending Food Shelf-Life and in the Prevention of Health Diseases: Encapsulation and Interfacial Phenomena.Biomedicines · 2021Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPomegranate extract (PE) is a natural product with potent antioxidant and anticancer activity because of its polyphenols content. The main purpose of this study was to maximize the PE chemotherapeutic efficacy by loading it in an optimized solid lipid nanoparticles (SLNs) formula. MATERIALS AND
methodsThe influence of independent variables, which were lipid concentration (X
resultsThe results demonstrated that the particle sizes ranged from 407.5 to 651.9 nm and the entrapment efficiencies ranged from 56.02 to 65.23%. Interestingly, the 50% inhibitory concentration of the optimized formula had more than a 40-fold improved effect on the cell growth inhibition in comparison with its free counterpart. Furthermore, it was more selective against cancer cells than normal cells particularly in MCF-7 breast cancer cells.
conclusionThese data proved that nanoencapsulation of PE enhanced its anticancer efficacy. Therefore, our results suggested that a PE-loaded SLNs optimized-formula could be a promising chemo therapeutic agent.
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Registered trials
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