ArticleWorld journal of gastroenterology2018
Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model.
Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 18 citations in OpenAlex.
- The origin of newborn hepatocytes in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)-derived regeneration.Hepatobiliary surgery and nutrition · 2020Article
- Comparison of functional and volumetric increase of the future remnant liver and postoperative outcomes after portal vein embolization and complete or partial associating liver partition and portal vein ligation for staged hepatectomy (ALPPS).Annals of translational medicine · 2020Article
- ALPPS for hepatocarcinoma under cirrhosis: a feasible alternative to portal vein embolization.Annals of translational medicine · 2019Review
- A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis.Experimental and therapeutic medicine · 2019Article
- Correction to "Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model [World J Gastroenterol 2018 March 14; 24(10): 1107-1119]".World journal of gastroenterology · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo establish a rat model for evaluating the maturity of liver regeneration derived from associating liver partition and portal vein ligation for staged hepatectomy (ALPPS).
methodsIn the present study, ALPPS, partial hepatecotmy (PHx), and sham rat models were established initially, which were validated by significant increase of proliferative markers including Ki-67, proliferating cell nuclear antigen, and cyclin D1. In the setting of accelerated proliferation in volume at the second and fifth day after ALPPS, the characteristics of newborn hepatocytes, as well as specific markers of progenitor hepatic cell, were identified. Afterwards, the detection of liver function followed by cluster analysis of functional gene expression were performed to evaluate the maturity.
resultsCompared with PHx and sham groups, the proliferation of FLR was significantly higher in ALPPS group (
conclusionOur study revealed the immaturity of ALPPS-derived proliferation in early regenerative response, which indicated that the volumetric assessment overestimated the functional proliferation. This could be convincing evidence that the stage II of ALPPS should be performed prudently in patients with marginally adequate FLR, as the ALPPS-derived proliferation in volume lags behind the functional regeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.