Evidence map›Paper›PMID 29563635›Full record

ArticleBritish journal of cancer2018

In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics.

Keely M McNamara, Fouzia Guestini, Torill Sauer, Joel Touma, Ida Rashida Bukholm, Jonas C Lindstrøm, Hironobu Sasano, Jürgen Geisler

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Keely M McNamaraDepartment of Anatomic Pathology, School of Graduate Medicine, Tohoku University Japan, Sendai, Japan. kmcnamara@patholo2.med.tohoku.ac.jp.
Fouzia GuestiniDepartment of Anatomic Pathology, School of Graduate Medicine, Tohoku University Japan, Sendai, Japan.
Torill SauerDepartment of Pathology, Akershus University Hospital, Lørenskog, Norway.
Joel ToumaInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ida Rashida BukholmDepartment of Breast- and Endocrine Surgery, Akershus University Hospital, Lørenskog, Norway.
Jonas C LindstrømInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Hironobu SasanoDepartment of Anatomic Pathology, School of Graduate Medicine, Tohoku University Japan, Sendai, Japan.
Jürgen GeislerInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Akershus University Hospital · NOTohoku University · JPUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe majority of breast cancer cases are steroid dependent neoplasms, with hormonal manipulation of either CYP19/aromatase or oestrogen receptor alpha axis being the most common therapy. Alternate pathways of steroid actions are documented, but their interconnections and correlations to BC subtypes and clinical outcome could be further explored.

methodsWe evaluated selected steroid receptors (Androgen Receptor, Oestrogen Receptor alpha and Beta, Glucocorticoid Receptor) and oestrogen pathways (steroid sulfatase (STS), 17β-hydroxysteroid dehydrogenase 2 (17βHSD2) and aromatase) in a cohort of 139 BC cases from Norway. Using logistic and cox regression analysis, we examined interactions between these and clinical outcomes such as distant metastasis, local relapse and survival.

resultsOur principal finding is an impact of STS expression on the risk for distant metastasis (p<0.001) and local relapses (p <0.001), HER2 subtype (p<0.015), and survival (p<0.001). The suggestion of a beneficial effect of alternative oestrogen synthesis pathways was strengthened by inverted, but non-significant findings for 17βHSD2.

conclusionsIncreased intratumoural metabolism of oestrogens through STS is associated with significantly lower incidence of relapse and/or distant metastasis and correspondingly improved prognosis. The enrichment of STS in the HER2 overexpressing subtype is intriguing, especially given the possible role of HER-2 over-expression in endocrine resistance.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorBreast NeoplasmsFemaleHumansImmunohistochemistryMiddle AgedNeoplasm InvasivenessPrognosisSteryl-SulfataseBiomarkers, TumorSteryl-SulfataseSTS protein, human

Identifiers

PMID29563635
PMCPMC5943586
OpenAlexW2793513030

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.