Evidence map›Paper›PMID 29563613›Full record

ReviewCellular & molecular immunology2018

Chemokine and chemotactic signals in dendritic cell migration.

Laura Tiberio, Annalisa Del Prete, Tiziana Schioppa, Francesca Sozio, Daniela Bosisio, Silvano Sozzani

Abstract readReview
In one paragraph

Review in Cellular & molecular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  9. Article
  10. Article
  11. Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications.Chembiochem : a European journal of chemical biology · 2025
    Review
  12. Review
  13. Article
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  20. Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laura TiberioDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0003-0482-9898
Annalisa Del PreteDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Tiziana SchioppaDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Francesca SozioDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Daniela BosisioDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Silvano SozzaniDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. silvano.sozzani@unibs.it.ORCID http://orcid.org/0000-0002-3144-8743

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for the development of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas mature DCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs is strictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (danger-associated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and in concert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such as synergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complex scenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and will uncover new molecular targets for therapeutic interventions.

Indexed as

Cell MovementChemotaxisAnimalsChemokinesDendritic CellsHumansReceptors, ChemokineSignal TransductionChemokinesReceptors, Chemokine

Identifiers

PMID29563613
PMCPMC6052805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.