ArticleScientific reports2018
Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Novel MRI Quantification Free Breathing Technique in Evaluation of Liver Lesions
Technical Development and Clinical Validation of a Comprehensive One-stop Shop Assessment of the Cirrhotic Liver With [68Ga]Ga-PSMA-11 PET/MRI
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Lower diffusion-derived vessel density (DDVD) measure of liver focal nodular hyperplasia than those of hepatocellular carcinoma and liver metastasis allows potential differential diagnosis: quantitative and semi-quantitative analyses of two-center data.Journal of gastrointestinal oncology · 2025Article
- Evaluating the Impact of Liver Vasculature Model Complexity for Estimating Dose to Circulating Blood During Radiation Therapy.International journal of radiation oncology, biology, physics · 2025Article
- The impacts of time of echo (TE) and time of repetition (TR) on diffusion-derived 'vessel density' (DDVD) measurement: examples of liver, spleen, and hepatocellular carcinoma.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Medical Radiology: Current Progress.Diagnostics (Basel, Switzerland) · 2023Review
- Hepatocellular carcinoma: State of the art diagnostic imaging.World journal of radiology · 2023Review
- Imaging Diagnosis of Hepatocellular Carcinoma: A State-of-the-Art Review.Diagnostics (Basel, Switzerland) · 2023Review
- Quantitative magnetic resonance imaging for focal liver lesions: bridging the gap between research and clinical practice.The British journal of radiology · 2021Review
- Correlation of radiomic features on dynamic contrast-enhanced magnetic resonance with microvessel density in hepatocellular carcinoma based on different models.The Journal of international medical research · 2021Article
- Imaging biomarkers of diffuse liver disease: current status.Abdominal radiology (New York) · 2020Article
- Signal changes in T2-weighted MRI of liver metastases under bevacizumab-A practical imaging biomarker?PloS one · 2020Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Funding
Abstract
We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48-72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hospital, Shanghai, China on a 1.5 T MRI. Contrast-enhanced volumetric T1-weighted images were acquired and a dual-input single-compartment model used to derive arterial fraction (AF), distribution volume (DV) and mean transit time (MTT) for the lesions and normal parenchyma. The measurements were compared using two-tailed Student's t-test, with Bonferroni correction applied for multiple-comparison testing. 28 hepatocellular carcinoma (HCC) and 17 metastatic lesions were evaluated. No significant difference was noted in perfusion parameters of normal liver parenchyma and neoplastic masses at two centers (p = 0.62 for AF, 0.015 for DV, 0.42 for MTT for HCC, p = 0.13 for AF, 0.97 for DV, 0.78 for MTT for metastases). There was statistically significant difference in AF, DV, and MTT of metastases and AF and DV of HCC compared to normal liver parenchyma (p < 0.5/9 = 0.0055). A statistically significant difference was noted in the MTT of metastases compared to hepatocellular carcinoma (p < 0.001*10-5). In conclusion, 3D Spiral-GRAPPA enabled quantitative free-breathing perfusion MRI exam provides robust perfusion parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.