Trial reportScientific reports2018
Using high-amplitude and focused transcranial alternating current stimulation to entrain physiological tremor.
Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- No effect of anodal high-definition transcranial direct current stimulation during motor sequence learning in older people.GeroScience · 2026Trial
- Differences in high-definition transcranial direct current stimulation over the motor hotspot versus the premotor cortex on motor network excitability.Scientific reports · 2019Trial
- Neuronal effects of epicranial current stimulation in macaque cortex.Frontiers in neuroscience · 2025Article
- Computational analysis of electrode structure and configuration for efficient and localized neural stimulation.Biomedical engineering letters · 2024Article
- Frequency-Specific Modulation of Slow-Wave Neural Oscillations via Weak Exogeneous Extracellular Fields Reveals a Resonance Pattern.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Improving the Effect of Transcranial Alternating Current Stimulation (tACS): A Systematic Review.Frontiers in human neuroscience · 2021Review
- A Computational Modeling Study to Investigate the Use of Epicranial Electrodes to Deliver Interferential Stimulation to Subcortical Regions.Frontiers in neuroscience · 2021Article
- tACS entrains neural activity while somatosensory input is blocked.PLoS biology · 2020Article
- Current challenges: the ups and downs of tACS.Experimental brain research · 2019Review
- Hilbert transform-based time-series analysis of the circadian gene regulatory network.IET systems biology · 2019Article
- tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves.Nature communications · 2019Article
- Investigating the Feasibility of Epicranial Cortical Stimulation Using Concentric-Ring Electrodes: A Novel Minimally Invasive Neuromodulation Method.Frontiers in neuroscience · 2019Article
- Can Transcranial Electrical Stimulation Localize Brain Function?Frontiers in psychology · 2019Review
- Neural Oscillations and the Initiation of Voluntary Movement.Frontiers in psychology · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method that can entrain physiological tremor in healthy volunteers. We conducted two experiments to investigate the effectiveness of high-amplitude and focused tACS montages at entraining physiological tremor. Experiment 1 used saline-soaked sponge electrodes with an extra-cephalic return electrode and compared the effects of a motor (MC) and prefrontal cortex (PFC) electrode location. Average peak-amplitude was 1.925 mA. Experiment 2 used gel-filled cup-electrodes in a 4 × 1 focused montage and compared the effects of MC and occipital cortex (OC) tACS. Average peak-amplitude was 4.45 mA. Experiment 1 showed that unfocused MC and PFC tACS both produced phosphenes and significant phase entrainment. Experiment 2 showed that focused MC and OC tACS produced no phosphenes but only focused MC tACS caused significant phase entrainment. At the group level, tACS did not have a significant effect on tremor amplitude. However, with focused tACS there was a significant correlation between phase entrainment and tremor amplitude modulation: subjects with higher phase entrainment showed more tremor amplitude modulation. We conclude that: (1) focused montages allow for high-amplitude tACS without phosphenes and (2) high amplitude focused tACS can entrain physiological tremor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.