ArticleScientific reports2018
Cardiogenic Airflow in the Lung Revealed Using Synchrotron-Based Dynamic Lung Imaging.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Location, Location, Location: Spatial Immune-Stroma Crosstalk Drives Pathogenesis in Asthma.Immunological reviews · 2025Review
- Apneic uptake of atmospheric OJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Using X-ray velocimetry to measure lung function and assess the efficacy of a pseudomonas aeruginosa bacteriophage therapy for cystic fibrosis.Scientific reports · 2024Article
- Deep 3D reconstruction of synchrotron X-ray computed tomography for intact lungs.Scientific reports · 2023Article
- Quantification of muco-obstructive lung disease variability in mice via laboratory X-ray velocimetry.Scientific reports · 2020Article
- Methods for dynamic synchrotron X-ray respiratory imaging in live animals.Journal of synchrotron radiation · 2020Article
- Strain, strain rate, and mechanical power: An optimization comparison for oscillatory ventilation.International journal for numerical methods in biomedical engineering · 2019Article
- Airway Transmural Pressures in an Airway Tree During Bronchoconstriction in Asthma.Journal of engineering and science in medical diagnostics and therapy · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The beating heart is known to produce pressure and airflow oscillations in the lungs of mammals. This phenomenon is often disregarded as detailed measurement of its effects in the lung have hitherto not been possible. Previous studies have attempted to measure the effect of these oscillations on gas mixing. However, the results have proven inconclusive, due to the lack of a direct measurement tool capable of flow measurement throughout the entire bronchial tree. Here we present the first detailed measurement of cardiogenic oscillations, using synchrotron-based dynamic lung imaging of live mechanically ventilated mice. The results demonstrate large flow oscillations and pendelluft in the airways due to the mechanical action of the beating heart. Using a virtual tracer modelling analysis we show that cardiogenic oscillations produced up to 4 times increased gas mixing, but only in the absence of tidal ventilation. The results highlight the importance of considering this often-disregarded phenomenon when investigating lung function, particularly in situations where tidal ventilation is reduced or absent.
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