Evidence map›Paper›PMID 29563581›Full record

ArticleNature communications2018

A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues.

Hao Wan, Jingying Yue, Shoujun Zhu, Takaaki Uno, Xiaodong Zhang, Qinglai Yang, Kuai Yu, Guosong Hong, Junying Wang, Lulin Li and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 1 pooled it
25.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 1 synthesis or guideline pooled it, 443 citations in OpenAlex.

  1. Molecular fluorophores for in vivo bioimaging in the second near-infrared window.European journal of nuclear medicine and molecular imaging · 2022
    Pooled it
  2. Article
  3. Injectable natural hydrogel-loaded TaCommunications chemistry · 2026
    Article
  4. In Vivo Microendoscopy in the Near-Infrared II Window.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  5. Review
  6. Article
  7. Ultrabright NIR-II Nanoprobes forACS nanoscience Au · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Regenerative biomaterials · 2025
    Article
  18. Review
  19. Article
  20. Article

77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Hao WanDepartment of Materials Science and Engineering, South University of Science and Technology of China, 518055, Shenzhen, China.
Jingying YueDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Shoujun ZhuDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-2412-6121
Takaaki UnoDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Xiaodong ZhangDepartment of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, 300350, Tianjin, China.
Qinglai YangDepartment of Materials Science and Engineering, South University of Science and Technology of China, 518055, Shenzhen, China.
Kuai YuDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Guosong HongDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Junying WangDepartment of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, 300350, Tianjin, China.
Lulin LiPalo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Zhuoran MaDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Hongpeng GaoDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Yeteng ZhongDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Jessica SuDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Alexander L AntarisDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Yan XiaDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Jian LuoPalo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.ORCID http://orcid.org/0000-0002-2064-8467
Yongye LiangDepartment of Materials Science and Engineering, South University of Science and Technology of China, 518055, Shenzhen, China. liangyy@sustc.edu.cn.
Hongjie DaiDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA. hdai@stanford.edu.
Stanford University · USSouthern University of Science and Technology · CNTianjin University · CNVA Palo Alto Health Care System · USStanford Medicine · USYokkaichi University · JP

Funding

Human Infrared Vision at Molecular and Cellular ScaleDP1NS105737 · NINDS · STANFORD UNIVERSITY · PI DAI, HONGJIE · 2017 to 2022
$5.5M
NINDS NIH HHS DP1 NS105737
6 · The paper itself

Abstract

Fluorescence imaging of biological systems in the second near-infrared (NIR-II, 1000-1700 nm) window has shown promise of high spatial resolution, low background, and deep tissue penetration owing to low autofluorescence and suppressed scattering of long wavelength photons. Here we develop a bright organic nanofluorophore (named p-FE) for high-performance biological imaging in the NIR-II window. The bright NIR-II >1100 nm fluorescence emission from p-FE affords non-invasive in vivo tracking of blood flow in mouse brain vessels. Excitingly, p-FE enables one-photon based, three-dimensional (3D) confocal imaging of vasculatures in fixed mouse brain tissue with a layer-by-layer imaging depth up to ~1.3 mm and sub-10 µm high spatial resolution. We also perform in vivo two-color fluorescence imaging in the NIR-II window by utilizing p-FE as a vasculature imaging agent emitting between 1100 and 1300 nm and single-walled carbon nanotubes (CNTs) emitting above 1500 nm to highlight tumors in mice.

Indexed as

AnimalsBlood VesselsBrainCell Line, TumorCerebrovascular CirculationFemaleFluorescent DyesImaging, Three-DimensionalInjections, SubcutaneousMammary Glands, AnimalMiceMice, Inbred BALB CMice, Inbred C57BLNanotubes, CarbonNeoplasm TransplantationOptical ImagingFluorescent DyesNanotubes, Carbon

Identifiers

PMID29563581
PMCPMC5862886
OpenAlexW2794186026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.