Evidence map›Paper›PMID 29563553›Full record

ArticleScientific reports2018

Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source.

Mareike Töpperwien, Regine Gradl, Daniel Keppeler, Malte Vassholz, Alexander Meyer, Roland Hessler, Klaus Achterhold, Bernhard Gleich, Martin Dierolf, Franz Pfeiffer and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

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  8. Multiscale photonic imaging of the native and implanted cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 2 countries.

Mareike TöpperwienInstitute for X-Ray Physics, University of Göttingen, Göttingen, Germany.
Regine GradlChair of Biomedical Physics, Department of Physics, Technical University of Munich, Garching, Germany.
Daniel KeppelerInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.
Malte VassholzInstitute for X-Ray Physics, University of Göttingen, Göttingen, Germany.
Alexander MeyerInnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, Göttingen, Germany.
Roland HesslerMED-EL Company, Innsbruck, Austria.
Klaus AchterholdChair of Biomedical Physics, Department of Physics, Technical University of Munich, Garching, Germany.ORCID 0000-0002-8724-1637
Bernhard GleichMunich School of BioEngineering, Technical University of Munich, Garching, Germany.
Martin DierolfChair of Biomedical Physics, Department of Physics, Technical University of Munich, Garching, Germany.ORCID 0000-0001-5150-2949
Franz PfeifferChair of Biomedical Physics, Department of Physics, Technical University of Munich, Garching, Germany.
Tobias MoserCenter for Nanoscopy and Molecular Physiology of the Brain, Göttingen, Germany.ORCID 0000-0001-7145-0533
Tim SaldittInstitute for X-Ray Physics, University of Göttingen, Göttingen, Germany. tsaldit@gwdg.de.ORCID 0000-0003-4636-0813
Technical University of Munich · DEUniversitätsmedizin Göttingen · DEBernstein Center for Computational Neuroscience Göttingen · DEGesellschaft für wissenschaftliche Datenverarbeitung mbH Göttingen · DEInstitute for Advanced Study · DEMED-EL (Austria) · ATNanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 · DETUM Klinikum · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We demonstrate that phase retrieval and tomographic imaging at the organ level of small animals can be advantageously carried out using the monochromatic radiation emitted by a compact x-ray light source, without further optical elements apart from source and detector. This approach allows to carry out microtomography experiments which - due to the large performance gap with respect to conventional laboratory instruments - so far were usually limited to synchrotron sources. We demonstrate the potential by mapping the functional soft tissue within the guinea pig and marmoset cochlea, including in the latter case an electrical cochlear implant. We show how 3d microanatomical studies without dissection or microscopic imaging can enhance future research on cochlear implants.

Indexed as

Tomography, X-Ray ComputedAnimalsCallithrixCochleaGuinea PigsSynchrotrons

Identifiers

PMID29563553
PMCPMC5862924
OpenAlexW2795272344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.