ArticleScientific reports2018
The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- TEX43, a testis-enriched microtubule-associated gene, exerts minimal impact on spermatogenesis and fertility in mice and humans.Journal of assisted reproduction and genetics · 2026Article
- Normal spermatogenesis and fertility inBiochemistry and biophysics reports · 2026Article
- Region-specific transcriptomic responses to CD52 deficiency in the male reproductive tract.BMC genomics · 2026Article
- NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis.Nature communications · 2025Article
- CCDC146 is required for sperm flagellum biogenesis and male fertility in mice.Cellular and molecular life sciences : CMLS · 2023Article
- Identification of hub genes associated with spermatogenesis by bioinformatics analysis.Scientific reports · 2023Article
- Fbxw17 is dispensable for viability and fertility in mice.Molecular biology reports · 2022Article
- Integrated analyses of an RNA binding protein-based signature related to tumor immune microenvironment and candidate drugs in osteosarcoma.American journal of translational research · 2022Article
- A Role of the TEX101 Interactome in the Common Aetiology Behind Male Subfertility and Testicular Germ Cell Tumor.Frontiers in oncology · 2022Review
- Coiled-Coil Domain-Containing (CCDC) Proteins: Functional Roles in General and Male Reproductive Physiology.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Inactivation of testis-specific gene C4orf46 is dispensable for spermatogenesis and fertility in mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer.Cancer discovery · 2021Article
- CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice.Scientific reports · 2021Article
- Testis-expressed protein 33 is not essential for spermiogenesis and fertility in mice.Molecular medicine reports · 2021Article
- Human testis-expressed (TEX) genes: a review focused on spermatogenesis and male fertility.Basic and clinical andrology · 2021Review
- PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice.Journal of cellular and molecular medicine · 2021Article
- SPATS1 (spermatogenesis-associated, serine-rich 1) is not essential for spermatogenesis and fertility in mouse.PloS one · 2021Article
- Structural and Functional Characterization of a Testicular Long Non-coding RNAFrontiers in cell and developmental biology · 2021Article
- MeiosisOnline: A Manually Curated Database for Tracking and Predicting Genes Associated With Meiosis.Frontiers in cell and developmental biology · 2021Article
- Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are more than 2300 genes that are predominantly expressed in mouse testes. The role of hundreds of these genes has been studied in mouse spermatogenesis but still there are many genes whose function is unknown. Gene knockout (KO) strategy in mice is widely used for in vivo study of gene function. The present study was designed to explore the function of the four genes: Tex37, Ccdc73, Prss55 and Nxt2, which were evolutionarily conserved in eutherians. We found that these genes had a testis-enriched expression pattern in mice except Nxt2. We knocked out these genes by CRISPR/Cas9 individually and found that all the KO mice had normal fertility with no detectable difference in testis/body weight ratios, epididymal sperm counts, as well as testicular and epididymal histology from wild type mice. Although these genes are evolutionarily conserved in eutherians including human and mouse, they are not individually essential for spermatogenesis, testis development and male fertility in mice in laboratory conditions. Our report of these fertile KO data could avoid the repetition and duplication of efforts which will help in prioritizing efforts to focus on genes that are indispensable for male reproduction.
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