ArticleScientific reports2018
Dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 71 citations in OpenAlex.
- Effects ofAnimals : an open access journal from MDPI · 2026Article
- Multi-omics analysis reveals the modulatory effects ofFrontiers in microbiology · 2026Article
- Systemic and Retinal Protective Effects of Butyrate in Early Type 2 Diabetes via Gut Microbiota-Lipid Metabolism Interaction.Nutrients · 2025Article
- Evaluation of Dietary Additives on Yellowtail Kingfish (Aquaculture nutrition · 2025Article
- Elevated butyric acid and histamine in feces and serum as an indicator of onset of necrotic enteritis in broiler chickens.Frontiers in microbiology · 2025Article
- Study on the protective effect ofFood science & nutrition · 2024Article
- Feed additives and enrichment materials to reduce chicken stress, maximize productivity, and improve welfare.Veterinary world · 2024Review
- Dietary Supplementation of Crossbred Pigs with Glycerol, Vitamin C, and Niacinamide Alters the Composition of Gut Flora and Gut Flora-Derived Metabolites.Animals : an open access journal from MDPI · 2024Article
- Effects of DietaryAntioxidants (Basel, Switzerland) · 2024Article
- Addition of Butyric Acid and Lauric Acid Glycerides in Nursery Pig Feed to Replace Conventional Growth Promoters.Animals : an open access journal from MDPI · 2024Article
- Sodium butyrate administration improves intestinal development of suckling lambs.Journal of animal science · 2024Article
- Article
- The effect of butyric acid and nucleotides supplementation on broiler (Open veterinary journal · 2024Article
- Glycerol and reuterin-producing Limosilactobacillus reuteri enhance butyrate production and inhibit Enterobacteriaceae in broiler chicken cecal microbiota PolyFermS model.BMC microbiology · 2023Article
- Effects of DietaryAnimals : an open access journal from MDPI · 2023Article
- Effects of antimicrobial peptide and tributyrin on fecal microflora and blood indices of female calves.Food science & nutrition · 2023Article
- Sodium butyrate ameliorates diabetic retinopathy in mice via the regulation of gut microbiota and related short-chain fatty acids.Journal of translational medicine · 2023Article
- Integrated Serum Metabolome and Gut Microbiome to Decipher Chicken Amino Acid Improvements Induced by Medium-Chain Monoglycerides.Metabolites · 2023Article
- Alterations in Intestinal Antioxidant and Immune Function and Cecal Microbiota of Laying Hens Fed on Coated Sodium Butyrate Supplemented Diets.Animals : an open access journal from MDPI · 2022Article
- Chemically Protected Sodium Butyrate Improves Growth Performance and Early Development and Function of Small Intestine in Broilers as One Effective Substitute for Antibiotics.Antibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Butyrate can modulate the immune response and energy expenditure of animals and enhance intestinal health. The present study investigated changes in the intestinal microbiota composition and serum metabolites of young broilers in response to 3,000 ppm butyrate in the form of butyrate glycerides (BG) via pyrosequencing of bacterial 16S rRNA genes and nuclear magnetic resonance (NMR). The dietary treatment did not affect the alpha diversity of intestinal microbiota, but altered its composition. Thirty-nine key operational taxonomic units (OTUs) in differentiating cecal microbiota community structures between BG treated and untreated chickens were also identified. Bifidobacterium was, in particular, affected by the dietary treatment significantly, showing an increase in not only the abundance (approximately 3 fold, P ≤ 0.05) but also the species diversity. The (NMR)-based analysis revealed an increase in serum concentrations of alanine, low-density and very low-density lipoproteins, and lipids (P ≤ 0.05) by BG. More interestingly, the dietary treatment also boosted (P ≤ 0.05) serum concentrations of bacterial metabolites, including choline, glycerophosphorylcholine, dimethylamine, trimethylamine, trimethylamine-N-oxide, lactate, and succinate. In conclusion, the data suggest the modulation of intestinal microbiota and serum metabolites by BG dietary treatment and potential contribution of intestinal bacteria to lipid metabolism/energy homeostasis in broilers.
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