Evidence map›Paper›PMID 29563491›Full record

ArticleNature communications2018

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.

Jason X Cheng, Li Chen, Yuan Li, Adam Cloe, Ming Yue, Jiangbo Wei, Kenneth A Watanabe, Jamile M Shammo, John Anastasi, Qingxi J Shen and 4 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 145 papers.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 226 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Coordinated DNA 5-mC and RNA mExperimental & molecular medicine · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. NSUN7-mediated mJournal of translational medicine · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Detection, molecular function and mechanisms of m5C in cancer.Clinical and translational medicine · 2025
    Review
  18. Article
  19. Article
  20. Review

85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Jason X ChengDepartment of Pathology, University of Chicago, Chicago, IL, 60637, USA. Jason.Cheng@uchospitals.edu.
Li ChenDepartment of Pathology, University of Chicago, Chicago, IL, 60637, USA.
Yuan LiDepartment of Pathology, University of Chicago, Chicago, IL, 60637, USA.
Adam CloeDepartment of Pathology, University of Chicago, Chicago, IL, 60637, USA.
Ming YueDepartment of Pathology, University of Chicago, Chicago, IL, 60637, USA.
Jiangbo WeiDepartment of Chemistry, University of Chicago, Chicago, IL, 60637, USA.
Kenneth A WatanabeGenomics Core, Emory University, Atlanta, GA, 30322, USA.
Jamile M ShammoRush University Medical Center, Chicago, IL, 60612, USA.
John AnastasiDepartment of Pathology, University of Chicago, Chicago, IL, 60637, USA.
Qingxi J ShenUniversity of Nevada, Las Vegas, NV, 89154, USA.
Richard A LarsonUniversity of Chicago Comprehensive Cancer Center, Chicago, IL, 60637, USA.
Chuan HeUniversity of Chicago Comprehensive Cancer Center, Chicago, IL, 60637, USA.ORCID http://orcid.org/0000-0003-4319-7424
Michelle M Le BeauUniversity of Chicago Comprehensive Cancer Center, Chicago, IL, 60637, USA.
James W VardimanDepartment of Pathology, University of Chicago, Chicago, IL, 60637, USA.
University of Chicago · USEmory University · USPeking University · CNRush University Medical Center · USUniversity of Nevada, Las Vegas · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1M
The Institute for Translational MedicineUL1TR002389 · NCATS · UNIVERSITY OF CHICAGO · PI Joshua J Jacobs, DAVID O MELTZER · 2017 to 2026
$71.6M
NCATS NIH HHS UL1 TR002389NCI NIH HHS P30 CA014599
6 · The paper itself

Abstract

The roles of RNA 5-methylcytosine (RNA:m

Indexed as

Gene Expression Regulation, LeukemicAntineoplastic AgentsAzacitidineBone MarrowBromodomain Containing ProteinsCell Cycle ProteinsCell Line, TumorChromatinChromatin Assembly and DisassemblyCyclin-Dependent Kinase 9CytosineDNA (Cytosine-5-)-MethyltransferasesDrug Resistance, NeoplasmGATA1 Transcription FactorHeterogeneous-Nuclear Ribonucleoprotein KHumansAntineoplastic AgentsAzacitidineBRD4 protein, humanBromodomain Containing ProteinsCDK9 protein, humanCell Cycle ProteinsChromatinCyclin-Dependent Kinase 9CytosineDNA (Cytosine-5-)-MethyltransferasesGATA1 protein, humanGATA1 Transcription FactorHeterogeneous-Nuclear Ribonucleoprotein KHNRNPK protein, humanMethyltransferasesNSUN2 protein, humanNSUN3 protein, humanNuclear ProteinsProto-Oncogene ProteinsProto-Oncogene Protein Spi-1RNA, NeoplasmRNA, Small InterferingTrans-ActivatorsTranscription FactorsTRDMT1 protein, human

Identifiers

PMID29563491
PMCPMC5862959
OpenAlexW2793661040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.