Evidence map›Paper›PMID 29563419›Full record

ArticleDentistry journal2017

Osteonecrosis of the Jaw (ONJ) in Osteoporosis Patients: Report of Delayed Diagnosis of a Multisite Case and Commentary about Risks Coming from a Restricted ONJ Definition.

Mario Migliario, Giovanni Mergoni, Paolo Vescovi, Iolanda De Martino, Manuela Alessio, Luca Benzi, Filippo Renò, Vittorio Fusco

Open access · goldAbstract readCase Reports
In one paragraph

Article in Dentistry journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Preventing, identifying, and managing medication-related osteonecrosis of the jaw: a practical guide for nurses and other allied healthcare professionals.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mario MigliarioDental Clinic, Health Sciences Department, University of Eastern Piedmont "A. Avogadro", 28100, Novara, Italy. mario.migliario@virgilio.it.ORCID 0000-0003-1627-4164
Giovanni MergoniOral Medicine and Laser Surgery Unit, University Center of Dentistry, Department of Medicine and Surgery, University of Parma, 43121, Parma, Italy. gmergon@gmail.com.
Paolo VescoviOral Medicine and Laser Surgery Unit, University Center of Dentistry, Department of Medicine and Surgery, University of Parma, 43121, Parma, Italy. paolo.vescovi@unipr.it.
Iolanda De MartinoCentro di Documentazione Osteonecrosi dei Mascellari, 15121,Alessandria, Italy. idemartino@ospedale.al.it.
Manuela AlessioCentro di Documentazione Osteonecrosi dei Mascellari, 15121,Alessandria, Italy. manuela.alessio@ospedale.al.it.
Luca BenziRadiology Unit, Alessandria Hospital, 15121, Alessandria, Italy. manuela.alessio@ospedale.al.it.
Filippo RenòInnovative Research Laboratory for Wound Healing, Health Sciences Department, University of Eastern Piedmont "A. Avogadro", 28100, Novara, Italy. vfusco@ospedale.al.it.
Vittorio FuscoCentro di Documentazione Osteonecrosi dei Mascellari, 15121,Alessandria, Italy. lbenzi@ospedale.al.it.
Azienda Sanitaria Locale Alessandria · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteonecrosis of the jaws (ONJ) in osteoporosis patients has been defined as rare, but the number of reported cases is increasing. We report a case of delayed ONJ diagnosis in a patient, who was being treated with alendronate, developing bone alterations both in maxilla and in mandible. Underestimation of ONJ incidence and missed or delayed ONJ diagnosis in osteoporosis patients might derive from lack of awareness of health providers as well as from an ONJ definition that is too restricted. The more recent definition of medication-related osteonecrosis of the jaws (MRONJ) released in 2014 by the American Association of Oral Maxillofacial Surgeons (AAOMS) accept fistula, besides bone exposure, as a major sign of disease, but it seems to be insufficient since it excludes all cases of ONJ disease without bone exposure. A new MRONJ definition is needed to avoid missing or delayed diagnosis.

Indexed as

alendronatebisphosphonateBRONJlaser therapyMRONJosteonecrosis of jawosteoporosis

Identifiers

PMID29563419
PMCPMC5806981
OpenAlexW2596110521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.