Evidence map›Paper›PMID 29563292›Full record

ArticleJournal of virology2018

Activation and Induction of Antigen-Specific T Follicular Helper Cells Play a Critical Role in Live-Attenuated Influenza Vaccine-Induced Human Mucosal Anti-influenza Antibody Response.

Abdullah Aljurayyan, Suttida Puksuriwong, Muhammad Ahmed, Ravi Sharma, Madhan Krishnan, Salil Sood, Katherine Davies, Devika Rajashekar, Sam Leong, Paul S McNamara and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 51 citations in OpenAlex.

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  14. Deletion of an immune evasion gene,Frontiers in immunology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Abdullah AljurayyanDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Suttida PuksuriwongDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Muhammad AhmedDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Ravi SharmaENT Department, Alder Hey Children's Hospital, Liverpool, United Kingdom.
Madhan KrishnanENT Department, Alder Hey Children's Hospital, Liverpool, United Kingdom.
Salil SoodENT Department, Alder Hey Children's Hospital, Liverpool, United Kingdom.
Katherine DaviesENT Department, Royal Liverpool and Broadgreen University Hospitals, Liverpool, United Kingdom.
Devika RajashekarENT Department, Royal Liverpool and Broadgreen University Hospitals, Liverpool, United Kingdom.
Sam LeongENT Department, Aintree University Hospital of Liverpool, Liverpool, United Kingdom.
Paul S McNamaraInstitute in the Park, Alder Hey Children's Hospital, Liverpool, United Kingdom.
Stephen GordonLiverpool School of Tropical Medicine, Liverpool, United Kingdom.
Qibo ZhangDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom Qibo.Zhang@liv.ac.uk.
University of Liverpool · GBRoyal Liverpool and Broadgreen University Hospital NHS Trust · GBAlder Hey Children's Hospital · GB

Funding

Medical Research Council MR/M011569/1
6 · The paper itself

Abstract

There is increasing interest recently in developing intranasal vaccines against respiratory tract infections. The antibody response is critical for vaccine-induced protection, and T follicular helper cells (T

Indexed as

Administration, IntranasalAdolescentAdultAntibodies, ViralAntibody FormationB-LymphocytesCD40 AntigensCD40 LigandCells, CulturedChildChild, PreschoolHemagglutinins, ViralHumansImmunity, MucosalInducible T-Cell Co-Stimulator ProteinInfluenza A Virus, H1N1 SubtypeAntibodies, ViralBCL6 protein, humanCD40 AntigensCD40 LigandHemagglutinins, ViralICOS protein, humanInducible T-Cell Co-Stimulator ProteinInfluenza VaccinesInterleukin-21InterleukinsProto-Oncogene Proteins c-bcl-6Receptors, Complement 3dVaccines, Attenuatedantibody responseinfluenza vaccineLAIVmucosal immunityNALTnasopharynx-associated lymphoid tissueTFHT follicular helper cell

Identifiers

PMID29563292
PMCPMC5952133
OpenAlexW2790138131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.