Evidence map›Paper›PMID 29563288›Full record

ArticleJournal of virology2018

Age-Associated Differences in Infection of Human Skin in the SCID Mouse Model of Varicella-Zoster Virus Pathogenesis.

Leigh Zerboni, Phillip Sung, Gordon Lee, Ann Arvin

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Review
  3. Animal models of human herpesvirus infection.Animal models and experimental medicine · 2025
    Review
  4. Review
  5. Blank Spots in the Map of Human Skin: The Challenge for Xenotransplantation.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Leigh ZerboniDepartment of Pediatrics; Stanford University School of Medicine, Stanford, California, USA zerboni@stanford.edu.
Phillip SungDepartment of Pediatrics; Stanford University School of Medicine, Stanford, California, USA.
Gordon LeeDivision of Plastic and Reconstructive Surgery; Stanford University School of Medicine, Stanford, California, USA.
Ann ArvinDepartment of Pediatrics; Stanford University School of Medicine, Stanford, California, USA.
Stanford University · US

Funding

Varicella-Zoster Virus: T Cell/Skin Tropisms &ImmunityR01AI020459 · NIAID · STANFORD UNIVERSITY · PI OLIVER, STEFAN LYNE · 1985 to 2023
$6.4M
Varicella-Zoster Virus: T Cell/Skin Tropisms & ImmunityR37AI020459 · NIAID · STANFORD UNIVERSITY · PI ARVIN, ANN · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI020459NIAID NIH HHS R37 AI020459
6 · The paper itself

Abstract

Varicella-zoster virus (VZV) is the skin-tropic human alphaherpesvirus responsible for both varicella-zoster and herpes zoster. Varicella-zoster and herpes zoster skin lesions have similar morphologies, but herpes zoster occurs disproportionally in older individuals and is often associated with a more extensive local rash and severe zoster-related neuralgia. We hypothesized that skin aging could also influence the outcome of the anterograde axonal transport of VZV to skin. We utilized human skin xenografts maintained in immunodeficient (SCID) mice to study VZV-induced skin pathology

Indexed as

AdultAgedAge FactorsAgingAnimalsDisease Models, AnimalEnzyme ActivationHerpesvirus 3, HumanHumansMiceMice, Inbred C57BLMice, Inbred NODMice, SCIDMiddle AgedPromyelocytic Leukemia ProteinSkinPML protein, humanPromyelocytic Leukemia ProteinSTAT3 protein, humanSTAT3 Transcription FactorinterferonsskinSTAT3transmissionvaricella-zoster virusviral pathogenesis

Identifiers

PMID29563288
PMCPMC5952162
OpenAlexW2793447381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.