ReviewProceedings. Biological sciences2018
Genetic diversity, inbreeding and cancer.
Review in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Genetic Diversity and Population Structure of WildAnimals : an open access journal from MDPI · 2026Article
- Dissecting cancer in a non-mammalian model: genomic insights from lemon frost geckos.BMC biology · 2026Article
- Gene expression and immune cell heterogeneity in inbred Amur tiger.BMC genomics · 2026Article
- Synchronous uterine leiomyosarcoma and pulmonary adenocarcinoma in a meerkat (Suricata suricatta): a case report.BMC veterinary research · 2025Article
- Isolation, Identification, and Characteristics ofPathogens (Basel, Switzerland) · 2025Article
- Genetic Diversity and Population Structure ofAnimals : an open access journal from MDPI · 2025Article
- Approaches and methods to study wildlife cancer.The Journal of animal ecology · 2024Review
- The complex effects of modern oncogenic environments on the fitness, evolution and conservation of wildlife species.Evolutionary applications · 2024Article
- The effect of body size and inbreeding on cancer mortality in breeds of the domestic dog: a test of the multi-stage model of carcinogenesis.Royal Society open science · 2024Article
- A Lesion on the "King of Kings": Neurofibromas in the Parthian Empire's Arsacid Dynasty.Cureus · 2023Review
- Article
- Unique genetic signature and selection footprints in Dutch population of German Longhaired Pointer dogs.Animal genetics · 2022Article
- Article
- Familial follicular cell thyroid carcinomas in a large number of Dutch German longhaired pointers.Veterinary and comparative oncology · 2022Article
- Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the "Perfect Storm" Theory.Pathogens (Basel, Switzerland) · 2022Article
- Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity.Pathogens (Basel, Switzerland) · 2021Article
- On the need for integrating cancer into the One Health perspective.Evolutionary applications · 2021Article
- Cancer: An unknown territory; rethinking before going ahead.Genes & diseases · 2021Review
- Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic diversity is essential for adaptive capacities, providing organisms with the potential of successfully responding to intrinsic and extrinsic challenges. Although a clear reciprocal link between genetic diversity and resistance to parasites and pathogens has been established across taxa, the impact of loss of genetic diversity by inbreeding on the emergence and progression of non-communicable diseases, such as cancer, has been overlooked. Here we provide an overview of such associations and show that low genetic diversity and inbreeding associate with an increased risk of cancer in both humans and animals. Cancer being a multifaceted disease, loss of genetic diversity can directly (via accumulation of oncogenic homozygous mutations) and indirectly (via increased susceptibility to oncogenic pathogens) impact abnormal cell emergence and escape of immune surveillance. The observed link between reduced genetic diversity and cancer in wildlife may further imperil the long-term survival of numerous endangered species, highlighting the need to consider the impact of cancer in conservation biology. Finally, the somewhat incongruent data originating from human studies suggest that the association between genetic diversity and cancer development is multifactorial and may be tumour specific. Further studies are therefore crucial in order to elucidate the underpinnings of the interactions between genetic diversity, inbreeding and cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.