Evidence map›Paper›PMID 29563170›Full record

ArticleThe European respiratory journal2018

Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland.

Charlotte Warren-Gash, Ruth Blackburn, Heather Whitaker, Jim McMenamin, Andrew C Hayward

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03816059 (Respiratory Virus Infections in Acutely Hospitalized Adult Patients With Pulmonary and Extrapulmonary Complications), which is not on this map. Cited by 146 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 8 pooled it
20.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03816059 unknown statusnot on this mapstarted 2019, after this paper: background citation

Respiratory Virus Infections in Acutely Hospitalized Adult Patients With Pulmonary and Extrapulmonary Complications

TypeobservationalSponsorThe University of Hong KongRan2019 to 2020Enrolled200ConditionsRespiratory Virus Infection, Stroke, Lung Disease, Acute Coronary SyndromeArmsRespiratory virus testing
3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 8 syntheses or guidelines pooled it, 259 citations in OpenAlex.

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  8. Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVID-19-systematic review, meta-analysis, and meta-regression.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020
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  19. Does influenza vaccination protect people with breakthrough infections from acute cardiovascular events?Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  20. Comprehensive Analysis of Cardiovascular Events and Risk Factors in Patients Hospitalized With Respiratory Syncytial Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Charlotte Warren-GashFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-4524-3180
Ruth BlackburnInstitute of Health Informatics, University College London, London, UK.
Heather WhitakerSchool of Mathematics and Statistics, Open University, Milton Keynes, UK.
Jim McMenaminHealth Protection Scotland, NHS National Services Scotland, Glasgow, UK.
Andrew C HaywardInstitute of Health Informatics, University College London, London, UK.
University College London · GBHealth Protection Scotland · GBLondon School of Hygiene & Tropical Medicine · GBThe Open University · GB

Funding

Medical Research Council MR/L009005/1Wellcome Trust 201440/Z/16/ZWellcome Trust 201440_Z_16_Z
6 · The paper itself

Abstract

While acute respiratory tract infections can trigger cardiovascular events, the differential effect of specific organisms is unknown. This is important to guide vaccine policy.Using national infection surveillance data linked to the Scottish Morbidity Record, we identified adults with a first myocardial infarction or stroke from January 1, 2004 to December 31, 2014 and a record of laboratory-confirmed respiratory infection during this period. Using self-controlled case series analysis, we generated age- and season-adjusted incidence ratios (IRs) for myocardial infarction (n=1227) or stroke (n=762) after infections compared with baseline time.We found substantially increased myocardial infarction rates in the week after

Indexed as

Acute DiseaseAdultAgedAged, 80 and overDatabases, FactualFemaleHealth PolicyHumansIncidenceInfluenza, HumanInfluenza VaccinesMaleMiddle AgedMyocardial InfarctionPneumococcal VaccinesPneumonia, StaphylococcalInfluenza VaccinesPneumococcal VaccinesVaccines

Identifiers

PMID29563170
PMCPMC5898931
OpenAlexW2792467473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.