Evidence map›Paper›PMID 29563166›Full record

ArticleGenome research2018

Repeat associated mechanisms of genome evolution and function revealed by the

David Thybert, Maša Roller, Fábio C P Navarro, Ian Fiddes, Ian Streeter, Christine Feig, David Martin-Galvez, Mikhail Kolmogorov, Václav Janoušek, Wasiu Akanni and 36 more

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Machine learning reveals sequence and genomic context features underlyingbioRxiv : the preprint server for biology · 2026
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  5. Evolution of CTCF binding sites in the human genome.Molecular biology and evolution · 2026
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  7. Polymorphic 3D genome architecture mediated by transposable elements.bioRxiv : the preprint server for biology · 2026
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  10. The Sikkim mouse (bioRxiv : the preprint server for biology · 2025
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  11. Article
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  15. Accurate, scalable, and fully automated inference of species trees from raw genome assemblies using ROADIES.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  16. Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

46 authors at 14 institutions in 5 countries.

David ThybertEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Maša RollerEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Fábio C P NavarroYale University Medical School, Computational Biology and Bioinformatics Program, New Haven, Connecticut 06520, USA.
Ian FiddesDepartment of Biomolecular Engineering, University of California, Santa Cruz, California 95064, USA.
Ian StreeterEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Christine FeigUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, United Kingdom.
David Martin-GalvezEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Mikhail KolmogorovDepartment of Computer Science and Engineering, University of California, San Diego, La Jolla, California 92092, USA.
Václav JanoušekDepartment of Zoology, Faculty of Science, Charles University in Prague, 128 44 Prague, Czech Republic.
Wasiu AkanniEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Bronwen AkenEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Sarah AldridgeUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Varshith ChakrapaniEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
William ChowWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
Laura ClarkeEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Carla CumminsEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Anthony DoranWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
Matthew DunnWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
Leo GoodstadtWellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom.
Kerstin HoweYale University Medical School, Computational Biology and Bioinformatics Program, New Haven, Connecticut 06520, USA.
Matthew HowellEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Ambre-Aurore JosselinEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Robert C KarnDepartment of Medicine, College of Medicine, University of Arizona, Tuscon, Arizona 85724, USA.
Christina M LaukaitisDepartment of Medicine, College of Medicine, University of Arizona, Tuscon, Arizona 85724, USA.
Lilue JingtaoWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
Fergal MartinEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Matthieu MuffatoEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Stefanie NachtweideInstitute of Mathematics and Computer Science, University of Greifswald, Greifswald 17487, Germany.
Michael A QuailWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
Cristina SisuYale University Medical School, Computational Biology and Bioinformatics Program, New Haven, Connecticut 06520, USA.
Mario StankeInstitute of Mathematics and Computer Science, University of Greifswald, Greifswald 17487, Germany.
Klara StefflovaUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Cock Van OosterhoutSchool of Environmental Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
Frederic VeyrunesInstitut des Sciences de l'Evolution de Montpellier, Université Montpellier/CNRS, 34095 Montpellier, France.
Ben WardEarlham Institute, Norwich Research Park, Norwich NR4 7UH, United Kingdom.
Fengtang YangWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
Golbahar YazdanifarDepartment of Medicine, College of Medicine, University of Arizona, Tuscon, Arizona 85724, USA.
Amonida ZadissaEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
David J AdamsWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
Alvis BrazmaEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Mark GersteinYale University Medical School, Computational Biology and Bioinformatics Program, New Haven, Connecticut 06520, USA.
Benedict PatenDepartment of Biomolecular Engineering, University of California, Santa Cruz, California 95064, USA.
Son PhamBioturing Inc, San Diego, California 92121, USA.
Thomas M KeaneEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Duncan T OdomUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Paul FlicekEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
European Bioinformatics Institute · GBWellcome Sanger Institute · GBUniversity of Cambridge · GBYale University · USUniversity of Arizona · USUniversität Greifswald · DEUniversity of California, Santa Cruz · USBiopeptide (United States) · USCentre for Human Genetics · GBCentre National de la Recherche Scientifique · FRCharles University · CZNorwich Research Park · GBUniversity of California San Diego · USUniversity of East Anglia · GB

Funding

GENCODE Resource ProjectU41HG007234 · NHGRI · SANGER INSTITUTE · PI FLICEK, PAUL · 2013 to 2020
$20.3M
Training SubprojectU54HG007990 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H, PATTERSON, DAVID · 2014 to 2018
$14.8M
Cancer Research UK 20412European Research Council 615584Medical Research Council MR/R017565/1NHGRI NIH HHS U41 HG007234NHGRI NIH HHS U54 HG007990Wellcome Trust 202878/Z/16/Z
6 · The paper itself

Abstract

Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created chromosome-level assemblies of the

Indexed as

Evolution, MolecularPhylogenyAnimalsBinding SitesCCCTC-Binding FactorChromosomesGenomeKaryotypingLong Interspersed Nucleotide ElementsMiceMuridaeRetroelementsSpecies SpecificityCCCTC-Binding FactorCtcf protein, mouseRetroelements

Identifiers

PMID29563166
PMCPMC5880236
OpenAlexW2950454586

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.