ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2018
Are Metabolic Signatures Mediating the Relationship between Lifestyle Factors and Hepatocellular Carcinoma Risk? Results from a Nested Case-Control Study in EPIC.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Associations between Metabolomic Signatures of Persistent Smoking Effects and Lung Cancer Risk among Former Smokers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Obesity and cancer: Methodological frontiers for mechanistic discoveries.PLoS medicine · 2026Review
- Metabolomic insights into associations between adiposity markers and liver cancer risk: Results from a prospective cohort study and Mendelian randomization analysis.PLoS medicine · 2026Article
- Mediating Role of Plasma Biomarkers Associated with Metabolic Syndrome in Cognitive Decline Among Older Adults.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy.The Science of the total environment · 2025Article
- Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases.Journal of the American Heart Association · 2024Article
- Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency.Scientific reports · 2024Article
- Healthy lifestyle decreases the risk of the first incidence of non-communicable chronic disease and its progression to multimorbidity and its mediating roles of metabolic components: a prospective cohort study in China.The journal of nutrition, health & aging · 2024Article
- Suppression of hepatocellular carcinoma by Ulva lactuca ulvan via gut microbiota and metabolite interactions.Journal of advanced research · 2023Article
- Characteristics of Cancer Epidemiology Studies That Employ Metabolomics: A Scoping Review.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Circulating Metabolic Markers Related to the Diagnosis of Hepatocellular Carcinoma.Journal of oncology · 2022Review
- Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort.BMC medicine · 2021Article
- A New Pipeline for the Normalization and Pooling of Metabolomics Data.Metabolites · 2021Article
- Article
- NMR metabolomic profiles associated with long-term risk of prostate cancer.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium.International journal of cancer · 2020Article
- Mediation analysis of the alcohol-postmenopausal breast cancer relationship by sex hormones in the EPIC cohort.International journal of cancer · 2020Article
- Undetectable Free Aromatic Amino Acids in Nails of Breast Carcinoma: Biomarker Discovery by a Novel Metabolite Purification VTGE System.Frontiers in oncology · 2020Article
- Nutritional Metabolomics in Cancer Epidemiology: Current Trends, Challenges, and Future Directions.Current nutrition reports · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 2 institutions in 2 countries.
Nada AssiSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
Duncan C ThomasUniversity of Southern California, Los Angeles, California.
Michael LeitzmannDepartment of Epidemiology and Preventive Medicine, Regensburg University, Regensburg, Germany.
Magdalena StepienSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
Véronique ChajèsSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
Thierry PhilipUnité Cancer et Environnement, Centre Léon Bérard, Lyon, France.
Paolo VineisDepartment of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.
Christina BamiaHellenic Health Foundation, Athens, Greece.
Marie-Christine Boutron-RuaultUniversité Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Torkjel M SandangerDepartment of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway.
Amaia MolinuevoPublic Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia-San Sebastián, Spain.
Hendriek C BoshuizenNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Anneli SundkvistDepartment of Radiation Sciences Oncology, Umeå University, Umeå, Sweden.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ruth C TravisCancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
Kim OvervadThe Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark.
Elio RiboliDepartment of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.
Marc J GunterSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
Augustin ScalbertSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
Mazda JenabSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
Pietro FerrariSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France. ferrarip@iarc.fr.
Vivian ViallonSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
Institut Gustave Roussy · FRUniversity of Southern California · US
Funding
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5MShared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2015 to 2024
$17.6MCancer Research UK 14136Cancer Research UK 16491Cancer Research UK C570/A16491Cancer Research UK C8221/A19170Medical Research Council 1000143Medical Research Council MR/M012190/1NCI NIH HHS P01 CA196539NCI NIH HHS P01 CA196569World Health Organization 001
Abstract
PubMed holds no abstract for this paper.
Indexed as
Life StyleMetabolomeAgedBiomarkers, TumorBody Mass IndexCarcinoma, HepatocellularCase-Control StudiesEuropeFemaleHumansLiver Function TestsLiver NeoplasmsMaleMetabolomicsMiddle AgedProspective StudiesBiomarkers, Tumor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.