Evidence map›Paper›PMID 29563122›Full record

ArticleBlood advances2018

Epigenetic programming of T cells impacts immune reconstitution in hematopoietic stem cell transplant recipients.

Kristine Hardy, Corey Smith, Wen Juan Tu, Robert McCuaig, Archana Panikkar, Vijayendra Dasari, Fan Wu, Siok-Keen Tey, Geoffrey R Hill, Rajiv Khanna and 1 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kristine HardyFaculty of Education, Science, Technology, and Mathematics, University of Canberra, Canberra, ACT, Australia; and.ORCID 0000-0003-1660-4477
Corey SmithQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID 0000-0002-7550-9595
Wen Juan TuFaculty of Education, Science, Technology, and Mathematics, University of Canberra, Canberra, ACT, Australia; and.
Robert McCuaigFaculty of Education, Science, Technology, and Mathematics, University of Canberra, Canberra, ACT, Australia; and.
Archana PanikkarQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Vijayendra DasariQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Fan WuFaculty of Education, Science, Technology, and Mathematics, University of Canberra, Canberra, ACT, Australia; and.
Siok-Keen TeyQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Geoffrey R HillQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Rajiv KhannaQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID 0000-0003-2241-0353
Sudha RaoFaculty of Education, Science, Technology, and Mathematics, University of Canberra, Canberra, ACT, Australia; and.
QIMR Berghofer Medical Research Institute · AUUniversity of Canberra · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune reconstitution following hematopoietic stem cell transplantation (HSCT) is critical in preventing harmful sequelae in recipients with cytomegalovirus (CMV) infection. To understand the molecular mechanisms underlying immune reconstitution kinetics, we profiled the transcriptome-chromatin accessibility landscape of CMV-specific CD8

Indexed as

Epigenesis, GeneticImmune ReconstitutionCellular ReprogrammingChromatin Assembly and DisassemblyCytomegalovirusCytomegalovirus InfectionsGene Expression RegulationHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansT-Cell Antigen Receptor SpecificityT-LymphocytesTranscription FactorsTranscriptomeTransplant RecipientsVirus ReplicationTranscription Factors

Identifiers

PMID29563122
PMCPMC5873237
OpenAlexW2792950230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.