Evidence map›Paper›PMID 29562982›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2018

High rates of exposure to tuberculosis patients among HIV-infected health care workers in Botswana.

S S Shin, C Modongo, N M Zetola, Q Wang, T Phologolo, M Kestler, A Ho-Foster

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

S S ShinDepartment of Epidemiology, University of California Los Angeles Fielding School of Public Health, Los Angeles, California, USA.
C ModongoBotswana-UPenn Partnership, Gaborone, Botswana, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
N M ZetolaBotswana-UPenn Partnership, Gaborone, Botswana, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Q WangDepartment of Epidemiology, University of California Los Angeles Fielding School of Public Health, Los Angeles, California, USA.
T PhologoloDepartment of Family Medicine and Public Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
M KestlerDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
A Ho-FosterBotswana-UPenn Partnership, Gaborone, Botswana, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Nina Thawata Harawa · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BALDWIN, GAYLE COCITA · 1991 to 2018
$39.9M
Dynamics of TB and MDR TB transmission in areas with high HIV prevalenceR01AI097045 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ZETOLA, NICOLA MARIO · 2011 to 2015
$2.9M
The Effect of Mixed-strain Mycobacterium tuberculosis Infections on TB Treatment Outcomes in Botswana: A Retrospective Cohort Study.K01AI118559 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIN, SANGHYUK SAM · 2015 to 2019
$670k
NCATS NIH HHS UL1 TR000124NIAID NIH HHS K01 AI118559NIAID NIH HHS P30 AI028697NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI097045NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

objectiveTo compare daily exposure to tuberculosis (TB) patients between HIV-infected and non-HIV-infected health care workers (HCWs), and examine the uptake of antiretroviral therapy (ART) and isoniazid preventive therapy (IPT) among HIV-infected HCWs in Botswana.

designWe conducted a cross-sectional study among HCWs in 30 hospitals and clinics. We determined self-reported exposure frequency to TB patients and HIV status through in-person interviews. HCWs with unknown or negative HIV status were offered rapid HIV testing. Multivariable Poisson regression modeling with robust variance was used to estimate the association between HIV status and daily exposure to TB patients.

resultsOf 1877 participants enrolled, 1388 (73.9%) with complete data were included in this study. Among 277 (20.0%) HIV-infected participants, 14.3% were newly diagnosed, 57.8% were on ART, and 34.3% reported previously receiving IPT. Daily exposure to TB patients was reported by respectively 48.4% and 52.9% of HIV-infected and non-infected participants. After adjusting for sex, age, occupation, and department, the rates of daily TB exposure remained similar between HIV-infected and non-HIV-infected participants (prevalence ratio 0.96, 95%CI 0.85-1.08).

conclusionsWe found similar rates of exposure to TB patients between HIV-infected and non-HIV-infected HCWs. Improved efforts are needed to reduce nosocomial exposure to TB among HIV-infected HCWs.

Indexed as

AdultAntitubercular AgentsBotswanaCross InfectionCross-Sectional StudiesFemaleHealth PersonnelHIV InfectionsHumansIsoniazidMaleMiddle AgedMultivariate AnalysisOccupational ExposureRegression AnalysisTuberculosisAntitubercular AgentsIsoniazid

Identifiers

PMID29562982
PMCPMC5868425

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.